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Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic beta-cells.
Endocrinology. 2004 Jun;145(6):2845-57. doi: 10.1210/en.2003-0939. Epub 2004 Mar 4.
Endocrinology. 2004.
PMID: 15001544
Increased O-glycosylation of insulin signaling proteins results in their impaired activation and enhanced susceptibility to apoptosis in pancreatic beta-cells.
D'Alessandris C, Andreozzi F, Federici M, Cardellini M, Brunetti A, Ranalli M, Del Guerra S, Lauro D, Del Prato S, Marchetti P, Lauro R, Sesti G.
D'Alessandris C, et al.
FASEB J. 2004 Jun;18(9):959-61. doi: 10.1096/fj.03-0725fje. Epub 2004 Apr 1.
FASEB J. 2004.
PMID: 15059979
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C-reactive protein induces phosphorylation of insulin receptor substrate-1 on Ser307 and Ser 612 in L6 myocytes, thereby impairing the insulin signalling pathway that promotes glucose transport.
D'Alessandris C, Lauro R, Presta I, Sesti G.
D'Alessandris C, et al.
Diabetologia. 2007 Apr;50(4):840-9. doi: 10.1007/s00125-006-0522-y. Epub 2007 Feb 6.
Diabetologia. 2007.
PMID: 17279354
Free article.
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Control of mouse cumulus cell-oocyte complex integrity before and after ovulation: plasminogen activator synthesis and matrix degradation.
D'Alessandris C, Canipari R, Di Giacomo M, Epifano O, Camaioni A, Siracusa G, Salustri A.
D'Alessandris C, et al.
Endocrinology. 2001 Jul;142(7):3033-40. doi: 10.1210/endo.142.7.8277.
Endocrinology. 2001.
PMID: 11416025
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Hyaluronan synthesis by mouse cumulus cells is regulated by interactions between follicle-stimulating hormone (or epidermal growth factor) and a soluble oocyte factor (or transforming growth factor beta1).
Tirone E, D'Alessandris C, Hascall VC, Siracusa G, Salustri A.
Tirone E, et al. Among authors: d alessandris c.
J Biol Chem. 1997 Feb 21;272(8):4787-94. doi: 10.1074/jbc.272.8.4787.
J Biol Chem. 1997.
PMID: 9030534
Free article.
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Endocrine and paracrine regulation of cumulus expansion.
Salustri A, Camaioni A, D'Alessandris C.
Salustri A, et al. Among authors: d alessandris c.
Zygote. 1996 Nov;4(4):313-5. doi: 10.1017/s0967199400003312.
Zygote. 1996.
PMID: 9153772
Review.
No abstract available.
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Hyaluronic acid and proteoglycan accumulation in the cumulus oophorus matrix.
Salustri A, Camaioni A, Tirone E, D'Alessandris C.
Salustri A, et al. Among authors: d alessandris c.
Ital J Anat Embryol. 1995;100 Suppl 1:479-84.
Ital J Anat Embryol. 1995.
PMID: 11322326
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