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The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase.
Bioorg Med Chem Lett. 2004 Jun 7;14(11):2941-5. doi: 10.1016/j.bmcl.2004.03.052.
Bioorg Med Chem Lett. 2004.
PMID: 15125964
Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR.
Bilodeau MT, Cunningham AM, Koester TJ, Ciecko PA, Coll KE, Huckle WR, Hungate RW, Kendall RL, McFall RC, Mao X, Rutledge RZ, Thomas KA.
Bilodeau MT, et al. Among authors: koester tj.
Bioorg Med Chem Lett. 2003 Aug 4;13(15):2485-8. doi: 10.1016/s0960-894x(03)00485-2.
Bioorg Med Chem Lett. 2003.
PMID: 12852948
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Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel.
Bilodeau MT, Balitza AE, Koester TJ, Manley PJ, Rodman LD, Buser-Doepner C, Coll KE, Fernandes C, Gibbs JB, Heimbrook DC, Huckle WR, Kohl N, Lynch JJ, Mao X, McFall RC, McLoughlin D, Miller-Stein CM, Rickert KW, Sepp-Lorenzino L, Shipman JM, Subramanian R, Thomas KA, Wong BK, Yu S, Hartman GD.
Bilodeau MT, et al. Among authors: koester tj.
J Med Chem. 2004 Dec 2;47(25):6363-72. doi: 10.1021/jm049697f.
J Med Chem. 2004.
PMID: 15566305
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Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase.
Sisko JT, Tucker TJ, Bilodeau MT, Buser CA, Ciecko PA, Coll KE, Fernandes C, Gibbs JB, Koester TJ, Kohl N, Lynch JJ, Mao X, McLoughlin D, Miller-Stein CM, Rodman LD, Rickert KW, Sepp-Lorenzino L, Shipman JM, Thomas KA, Wong BK, Hartman GD.
Sisko JT, et al. Among authors: koester tj.
Bioorg Med Chem Lett. 2006 Mar 1;16(5):1146-50. doi: 10.1016/j.bmcl.2005.11.089. Epub 2005 Dec 20.
Bioorg Med Chem Lett. 2006.
PMID: 16368234
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