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An aminomethylpyrimidine DPP-IV inhibitor with improved properties.
Bioorg Med Chem Lett. 2004 Jul 5;14(13):3575-8. doi: 10.1016/j.bmcl.2004.04.048.
Bioorg Med Chem Lett. 2004.
PMID: 15177477
Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents.
Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Boehringer M, Hennig M, Kuhn B, Loeffler BM.
Peters JU, et al. Among authors: loeffler bm.
Bioorg Med Chem Lett. 2004 Mar 22;14(6):1491-3. doi: 10.1016/j.bmcl.2004.01.019.
Bioorg Med Chem Lett. 2004.
PMID: 15006388
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Aminomethylpyridines as DPP-IV inhibitors.
Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Zimmerli D, Boehringer M, Steger M, Loeffler BM.
Peters JU, et al. Among authors: loeffler bm.
Bioorg Med Chem Lett. 2004 Jul 5;14(13):3579-80. doi: 10.1016/j.bmcl.2004.04.049.
Bioorg Med Chem Lett. 2004.
PMID: 15177478
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Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.
Boehringer M, Fischer H, Hennig M, Hunziker D, Huwyler J, Kuhn B, Loeffler BM, Luebbers T, Mattei P, Narquizian R, Sebokova E, Sprecher U, Wessel HP.
Boehringer M, et al. Among authors: loeffler bm.
Bioorg Med Chem Lett. 2010 Feb 1;20(3):1106-8. doi: 10.1016/j.bmcl.2009.12.025. Epub 2009 Dec 6.
Bioorg Med Chem Lett. 2010.
PMID: 20031408
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Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Mattei P, Boehringer M, Di Giorgio P, Fischer H, Hennig M, Huwyler J, Koçer B, Kuhn B, Loeffler BM, Macdonald A, Narquizian R, Rauber E, Sebokova E, Sprecher U.
Mattei P, et al. Among authors: loeffler bm.
Bioorg Med Chem Lett. 2010 Feb 1;20(3):1109-13. doi: 10.1016/j.bmcl.2009.12.024. Epub 2009 Dec 6.
Bioorg Med Chem Lett. 2010.
PMID: 20031405
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Endothelin-1 and endothelin converting enzyme-1 in human atherosclerosis--novel targets for pharmacotherapy in atherosclerosis.
Ihling C, Bohrmann B, Schaefer HE, Technau-Ihling K, Loeffler BM.
Ihling C, et al. Among authors: loeffler bm.
Curr Vasc Pharmacol. 2004 Jul;2(3):249-58. doi: 10.2174/1570161043385718.
Curr Vasc Pharmacol. 2004.
PMID: 15320823
Review.
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Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis.
Ihling C, Szombathy T, Bohrmann B, Brockhaus M, Schaefer HE, Loeffler BM.
Ihling C, et al. Among authors: loeffler bm.
Circulation. 2001 Aug 21;104(8):864-9. doi: 10.1161/hc3301.094742.
Circulation. 2001.
PMID: 11514370
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Endothelin in the early phase of bone marrow transplantation.
Tsakiris DA, Luescher TF, Loeffler BM, Marbet GA, Speck B, Gratwohl A.
Tsakiris DA, et al. Among authors: loeffler bm.
Transplantation. 1994 Jan;57(2):300-1. doi: 10.1097/00007890-199401001-00030.
Transplantation. 1994.
PMID: 8310526
No abstract available.
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