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Page 1
Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives.
Imai M, Shiota T, Kataoka K, Tarby CM, Moree WJ, Tsutsumi T, Sudo M, Ramirez-Weinhouse MM, Comer D, Sun CM, Yamagami S, Tanaka H, Morita T, Hada T, Greene J, Barnum D, Saunders J, Myers PL, Kato Y, Endo N. Imai M, et al. Among authors: tarby cm. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5407-11. doi: 10.1016/j.bmcl.2004.08.008. Bioorg Med Chem Lett. 2004. PMID: 15454235
Small molecule antagonists of the CCR2b receptor. Part 2: Discovery process and initial structure-activity relationships of diamine derivatives.
Moree WJ, Kataoka K, Ramirez-Weinhouse MM, Shiota T, Imai M, Sudo M, Tsutsumi T, Endo N, Muroga Y, Hada T, Tanaka H, Morita T, Greene J, Barnum D, Saunders J, Kato Y, Myers PL, Tarby CM. Moree WJ, et al. Among authors: tarby cm. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5413-6. doi: 10.1016/j.bmcl.2004.08.009. Bioorg Med Chem Lett. 2004. PMID: 15454236
Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series.
Moree WJ, Kataoka K, Ramirez-Weinhouse MM, Shiota T, Imai M, Tsutsumi T, Sudo M, Endo N, Muroga Y, Hada T, Fanning D, Saunders J, Kato Y, Myers PL, Tarby CM. Moree WJ, et al. Among authors: tarby cm. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1869-73. doi: 10.1016/j.bmcl.2008.02.015. Epub 2008 Feb 10. Bioorg Med Chem Lett. 2008. PMID: 18313297
Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.
Williams DK, Chen XT, Tarby C, Kaltenbach R, Cai ZW, Tokarski JS, An Y, Sack JS, Wautlet B, Gullo-Brown J, Henley BJ, Jeyaseelan R, Kellar K, Manne V, Trainor GL, Lombardo LJ, Fargnoli J, Borzilleri RM. Williams DK, et al. Bioorg Med Chem Lett. 2010 May 1;20(9):2998-3002. doi: 10.1016/j.bmcl.2010.01.042. Epub 2010 Jan 20. Bioorg Med Chem Lett. 2010. PMID: 20382527
Modulation of cofilin phosphorylation by inhibition of the Lim family kinases.
He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY, Attar R, Lin TA. He L, et al. Among authors: tarby cm. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8. doi: 10.1016/j.bmcl.2012.07.002. Epub 2012 Jul 21. Bioorg Med Chem Lett. 2012. PMID: 22902653
Inhibitors of human mitotic kinesin Eg5: characterization of the 4-phenyl-tetrahydroisoquinoline lead series.
Tarby CM, Kaltenbach RF 3rd, Huynh T, Pudzianowski A, Shen H, Ortega-Nanos M, Sheriff S, Newitt JA, McDonnell PA, Burford N, Fairchild CR, Vaccaro W, Chen Z, Borzilleri RM, Naglich J, Lombardo LJ, Gottardis M, Trainor GL, Roussell DL. Tarby CM, et al. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2095-100. doi: 10.1016/j.bmcl.2006.01.056. Epub 2006 Feb 3. Bioorg Med Chem Lett. 2006. PMID: 16458511
Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
McDonnell PA, Yanchunas J, Newitt JA, Tao L, Kiefer SE, Ortega M, Kut S, Burford N, Goldfarb V, Duke GJ, Shen H, Metzler W, Doyle M, Chen Z, Tarby C, Borzilleri R, Vaccaro W, Gottardis M, Lu S, Crews D, Kim K, Lombardo L, Roussell DL. McDonnell PA, et al. Anal Biochem. 2009 Sep 1;392(1):59-69. doi: 10.1016/j.ab.2009.05.044. Epub 2009 Jun 2. Anal Biochem. 2009. PMID: 19497292
14 results