Darke PL - Search Results

1

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.

Young SD, Payne LS, Thompson WJ, Gaffin N, Lyle TA, Britcher SF, Graham SL, Schultz TH, Deana AA, Darke PL, et al. Young SD, et al. Among authors: darke pl. J Med Chem. 1992 May 15;35(10):1702-9. doi: 10.1021/jm00088a004. J Med Chem. 1992. PMID: 1588552

2

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.

Thompson WJ, Fitzgerald PM, Holloway MK, Emini EA, Darke PL, McKeever BM, Schleif WA, Quintero JC, Zugay JA, Tucker TJ, et al. Thompson WJ, et al. Among authors: darke pl. J Med Chem. 1992 May 15;35(10):1685-701. doi: 10.1021/jm00088a003. J Med Chem. 1992. PMID: 1588551

3

A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.

Tucker TJ, Lumma WC Jr, Payne LS, Wai JM, de Solms SJ, Giuliani EA, Darke PL, Heimbach JC, Zugay JA, Schleif WA, et al. Tucker TJ, et al. Among authors: darke pl. J Med Chem. 1992 Jul 10;35(14):2525-33. doi: 10.1021/jm00092a002. J Med Chem. 1992. PMID: 1635054

4

Design and synthesis of HIV protease inhibitors. Variations of the carboxy terminus of the HIV protease inhibitor L-682,679.

deSolms SJ, Giuliani EA, Guare JP, Vacca JP, Sanders WM, Graham SL, Wiggins JM, Darke PL, Sigal IS, Zugay JA, et al. deSolms SJ, et al. Among authors: darke pl. J Med Chem. 1991 Sep;34(9):2852-7. doi: 10.1021/jm00113a025. J Med Chem. 1991. PMID: 1910089

5

L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor.

Vacca JP, Guare JP, deSolms SJ, Sanders WM, Giuliani EA, Young SD, Darke PL, Zugay J, Sigal IS, Schleif WA, et al. Vacca JP, et al. Among authors: darke pl. J Med Chem. 1991 Mar;34(3):1225-8. doi: 10.1021/jm00107a050. J Med Chem. 1991. PMID: 2002465 No abstract available.

6

Benzocycloalkyl amines as novel C-termini for HIV protease inhibitors.

Lyle TA, Wiscount CM, Guare JP, Thompson WJ, Anderson PS, Darke PL, Zugay ZA, Emini EA, Schleif WA, Qunitero JC, et al. Lyle TA, et al. Among authors: darke pl. J Med Chem. 1991 Mar;34(3):1228-30. doi: 10.1021/jm00107a051. J Med Chem. 1991. PMID: 2002466 No abstract available.

7

The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Lee HY, Thompson WJ, Culberson C, Holloway MK, McKee SP, Munson PM, Duong TT, Smith AM, Darke PL, et al. Ghosh AK, et al. Among authors: darke pl. J Med Chem. 1994 Apr 15;37(8):1177-88. doi: 10.1021/jm00034a016. J Med Chem. 1994. PMID: 8164260

8

Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands.

Ghosh AK, Thompson WJ, Holloway MK, McKee SP, Duong TT, Lee HY, Munson PM, Smith AM, Wai JM, Darke PL, et al. Ghosh AK, et al. Among authors: darke pl. J Med Chem. 1993 Aug 6;36(16):2300-10. doi: 10.1021/jm00068a006. J Med Chem. 1993. PMID: 8360874

9

3-Tetrahydrofuran and pyran urethanes as high-affinity P2-ligands for HIV-1 protease inhibitors.

Ghosh AK, Thompson WJ, McKee SP, Duong TT, Lyle TA, Chen JC, Darke PL, Zugay JA, Emini EA, Schleif WA, et al. Ghosh AK, et al. Among authors: darke pl. J Med Chem. 1993 Jan 22;36(2):292-4. doi: 10.1021/jm00054a015. J Med Chem. 1993. PMID: 8423600 No abstract available.

10

Cyclic sulfolanes as novel and high affinity P2 ligands for HIV-1 protease inhibitors.

Ghosh AK, Thompson WJ, Lee HY, McKee SP, Munson PM, Duong TT, Darke PL, Zugay JA, Emini EA, Schleif WA, et al. Ghosh AK, et al. Among authors: darke pl. J Med Chem. 1993 Apr 2;36(7):924-7. doi: 10.1021/jm00059a019. J Med Chem. 1993. PMID: 8464047 No abstract available.

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