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Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system.
Högestätt ED, Jönsson BA, Ermund A, Andersson DA, Björk H, Alexander JP, Cravatt BF, Basbaum AI, Zygmunt PM. Högestätt ED, et al. Among authors: cravatt bf. J Biol Chem. 2005 Sep 9;280(36):31405-12. doi: 10.1074/jbc.M501489200. Epub 2005 Jun 29. J Biol Chem. 2005. PMID: 15987694 Free article.
Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase.
Thors L, Burston JJ, Alter BJ, McKinney MK, Cravatt BF, Ross RA, Pertwee RG, Gereau RW 4th, Wiley JL, Fowler CJ. Thors L, et al. Among authors: cravatt bf. Br J Pharmacol. 2010 Jun;160(3):549-60. doi: 10.1111/j.1476-5381.2010.00716.x. Br J Pharmacol. 2010. PMID: 20590565 Free PMC article.
Fatty acid amide hydrolase substrate specificity.
Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF. Boger DL, et al. Among authors: cravatt bf. Bioorg Med Chem Lett. 2000 Dec 4;10(23):2613-6. doi: 10.1016/s0960-894x(00)00528-x. Bioorg Med Chem Lett. 2000. PMID: 11128635
580 results