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The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Pelletier JP, Boileau C, Boily M, Brunet J, Mineau F, Geng C, Reboul P, Laufer S, Lajeunesse D, Martel-Pelletier J. Pelletier JP, et al. Among authors: reboul p. Arthritis Res Ther. 2005;7(5):R1091-102. doi: 10.1186/ar1788. Epub 2005 Jul 19. Arthritis Res Ther. 2005. PMID: 16207326 Free PMC article.
Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B(4) in osteoarthritic chondrocytes: role of transforming growth factor beta and eicosanoids.
Martel-Pelletier J, Mineau F, Fahmi H, Laufer S, Reboul P, Boileau C, Lavigne M, Pelletier JP. Martel-Pelletier J, et al. Among authors: reboul p. Arthritis Rheum. 2004 Dec;50(12):3925-33. doi: 10.1002/art.20632. Arthritis Rheum. 2004. PMID: 15593193 Free article.
In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: suppression of collagenase 1 and interleukin-1beta synthesis.
Jovanovic DV, Fernandes JC, Martel-Pelletier J, Jolicoeur FC, Reboul P, Laufer S, Tries S, Pelletier JP. Jovanovic DV, et al. Among authors: reboul p. Arthritis Rheum. 2001 Oct;44(10):2320-30. doi: 10.1002/1529-0131(200110)44:10<2320::aid-art394>3.0.co;2-p. Arthritis Rheum. 2001. PMID: 11665972 Free article.
85 results