Houslay MD - Search Results

1

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.

Mongillo M, Tocchetti CG, Terrin A, Lissandron V, Cheung YF, Dostmann WR, Pozzan T, Kass DA, Paolocci N, Houslay MD, Zaccolo M. Mongillo M, et al. Among authors: houslay md. Circ Res. 2006 Feb 3;98(2):226-34. doi: 10.1161/01.RES.0000200178.34179.93. Epub 2005 Dec 15. Circ Res. 2006. PMID: 16357307

2

Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process.

Terry R, Cheung YF, Praestegaard M, Baillie GS, Huston E, Gall I, Adams DR, Houslay MD. Terry R, et al. Among authors: houslay md. Cell Signal. 2003 Oct;15(10):955-71. doi: 10.1016/s0898-6568(03)00092-5. Cell Signal. 2003. PMID: 12873709

3

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins.

Bolger GB, McCahill A, Huston E, Cheung YF, McSorley T, Baillie GS, Houslay MD. Bolger GB, et al. Among authors: houslay md. J Biol Chem. 2003 Dec 5;278(49):49230-8. doi: 10.1074/jbc.M303772200. Epub 2003 Sep 18. J Biol Chem. 2003. PMID: 14500724 Free article.

4

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases.

Mongillo M, McSorley T, Evellin S, Sood A, Lissandron V, Terrin A, Huston E, Hannawacker A, Lohse MJ, Pozzan T, Houslay MD, Zaccolo M. Mongillo M, et al. Among authors: houslay md. Circ Res. 2004 Jul 9;95(1):67-75. doi: 10.1161/01.RES.0000134629.84732.11. Epub 2004 Jun 3. Circ Res. 2004. PMID: 15178638

5

TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling.

Abrahamsen H, Baillie G, Ngai J, Vang T, Nika K, Ruppelt A, Mustelin T, Zaccolo M, Houslay M, Taskén K. Abrahamsen H, et al. J Immunol. 2004 Oct 15;173(8):4847-58. doi: 10.4049/jimmunol.173.8.4847. J Immunol. 2004. PMID: 15470025

6

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene.

Wallace DA, Johnston LA, Huston E, MacMaster D, Houslay TM, Cheung YF, Campbell L, Millen JE, Smith RA, Gall I, Knowles RG, Sullivan M, Houslay MD. Wallace DA, et al. Among authors: houslay tm, houslay md. Mol Pharmacol. 2005 Jun;67(6):1920-34. doi: 10.1124/mol.104.009423. Epub 2005 Feb 28. Mol Pharmacol. 2005. PMID: 15738310

7

Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.

Kelly MP, Isiegas C, Cheung YF, Tokarczyk J, Yang X, Esposito MF, Rapoport DA, Fabian SA, Siegel SJ, Wand G, Houslay MD, Kanes SJ, Abel T. Kelly MP, et al. Among authors: houslay md. Neuropsychopharmacology. 2007 Mar;32(3):577-88. doi: 10.1038/sj.npp.1301099. Epub 2006 May 31. Neuropsychopharmacology. 2007. PMID: 16738544 Free PMC article.

8

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579.

Hill EV, Sheppard CL, Cheung YF, Gall I, Krause E, Houslay MD. Hill EV, et al. Among authors: houslay md. Cell Signal. 2006 Nov;18(11):2056-69. doi: 10.1016/j.cellsig.2006.07.018. Epub 2006 Aug 1. Cell Signal. 2006. PMID: 16973330

9

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.

Terrin A, Di Benedetto G, Pertegato V, Cheung YF, Baillie G, Lynch MJ, Elvassore N, Prinz A, Herberg FW, Houslay MD, Zaccolo M. Terrin A, et al. Among authors: houslay md. J Cell Biol. 2006 Nov 6;175(3):441-51. doi: 10.1083/jcb.200605050. J Cell Biol. 2006. PMID: 17088426 Free PMC article.

10

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling.

Houslay MD, Baillie GS, Maurice DH. Houslay MD, et al. Circ Res. 2007 Apr 13;100(7):950-66. doi: 10.1161/01.RES.0000261934.56938.38. Circ Res. 2007. PMID: 17431197 Review.

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