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HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus.
Kneteman NM, Howe AY, Gao T, Lewis J, Pevear D, Lund G, Douglas D, Mercer DF, Tyrrell DL, Immermann F, Chaudhary I, Speth J, Villano SA, O'Connell J, Collett M. Kneteman NM, et al. Among authors: tyrrell dl. Hepatology. 2009 Mar;49(3):745-52. doi: 10.1002/hep.22717. Hepatology. 2009. PMID: 19072827 Clinical Trial.
The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity.
Laporte MG, Jackson RW, Draper TL, Gaboury JA, Galie K, Herbertz T, Hussey AR, Rippin SR, Benetatos CA, Chunduru SK, Christensen JS, Coburn GA, Rizzo CJ, Rhodes G, O'Connell J, Howe AY, Mansour TS, Collett MS, Pevear DC, Young DC, Gao T, Tyrrell DL, Kneteman NM, Burns CJ, Condon SM. Laporte MG, et al. Among authors: tyrrell dl. ChemMedChem. 2008 Oct;3(10):1508-15. doi: 10.1002/cmdc.200800168. ChemMedChem. 2008. PMID: 18729128 No abstract available.
The cell biology of hepatitis C virus.
Joyce MA, Tyrrell DL. Joyce MA, et al. Among authors: tyrrell dl. Microbes Infect. 2010 Apr;12(4):263-71. doi: 10.1016/j.micinf.2009.12.012. Epub 2010 Jan 18. Microbes Infect. 2010. PMID: 20080204 Free article. Review.
223 results