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4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Fletcher SR, Burkamp F, Blurton P, Cheng SK, Clarkson R, O'Connor D, Spinks D, Tudge M, van Niel MB, Patel S, Chapman K, Marwood R, Shepheard S, Bentley G, Cook GP, Bristow LJ, Castro JL, Hutson PH, MacLeod AM. Fletcher SR, et al. Among authors: burkamp f. J Med Chem. 2002 Jan 17;45(2):492-503. doi: 10.1021/jm011030v. J Med Chem. 2002. PMID: 11784153
From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Zheng X, Hodgetts KJ, Brielmann H, Hutchison A, Burkamp F, Brian Jones A, Blurton P, Clarkson R, Chandrasekhar J, Bakthavatchalam R, De Lombaert S, Crandall M, Cortright D, Blum CA. Zheng X, et al. Among authors: burkamp f. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5217-21. doi: 10.1016/j.bmcl.2006.07.010. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870426
Development of a potent and selective cell penetrant Legumain inhibitor.
Ness KA, Eddie SL, Higgins CA, Templeman A, D'Costa Z, Gaddale KK, Bouzzaoui S, Jordan L, Janssen D, Harrison T, Burkamp F, Young A, Burden R, Scott CJ, Mullan PB, Williams R. Ness KA, et al. Among authors: burkamp f. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5642-5. doi: 10.1016/j.bmcl.2015.10.001. Epub 2015 Oct 9. Bioorg Med Chem Lett. 2015. PMID: 26522952
The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer.
Forsythe N, Refaat A, Javadi A, Khawaja H, Weir JA, Emam H, Allen WL, Burkamp F, Popovici V, Jithesh PV, Isella C, Labonte MJ, Mills IG, Johnston PG, Van Schaeybroeck S. Forsythe N, et al. Among authors: burkamp f. Mol Cancer Ther. 2018 Jun;17(6):1280-1290. doi: 10.1158/1535-7163.MCT-17-0603. Epub 2018 Feb 26. Mol Cancer Ther. 2018. PMID: 29483217 Free PMC article.