Sutherland A - Search Results

1

Structural insights into stereochemical inversion by diaminopimelate epimerase: an antibacterial drug target.

Pillai B, Cherney MM, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN. Pillai B, et al. Among authors: sutherland a. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8668-73. doi: 10.1073/pnas.0602537103. Epub 2006 May 24. Proc Natl Acad Sci U S A. 2006. PMID: 16723397 Free PMC article.

2

The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase.

Diaper CM, Sutherland A, Pillai B, James MN, Semchuk P, Blanchard JS, Vederas JC. Diaper CM, et al. Among authors: sutherland a. Org Biomol Chem. 2005 Dec 21;3(24):4402-11. doi: 10.1039/b513409a. Epub 2005 Nov 15. Org Biomol Chem. 2005. PMID: 16327902

3

Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.

Pillai B, Cherney M, Diaper CM, Sutherland A, Blanchard JS, Vederas JC, James MN. Pillai B, et al. Among authors: sutherland a. Biochem Biophys Res Commun. 2007 Nov 23;363(3):547-53. doi: 10.1016/j.bbrc.2007.09.012. Epub 2007 Sep 17. Biochem Biophys Res Commun. 2007. PMID: 17889830

4

Conjugate addition of radicals generated from diacyloxyiodobenzenes to dehydroamino acid derivatives; a synthesis of diaminopimelic acid analogues.

Sutherland A, Vederas JC. Sutherland A, et al. Chem Commun (Camb). 2002 Feb 7;(3):224-5. doi: 10.1039/b109343f. Chem Commun (Camb). 2002. PMID: 12120376

5

Bacterial diaminopimelate metabolism as a target for antibiotic design.

Cox RJ, Sutherland A, Vederas JC. Cox RJ, et al. Among authors: sutherland a. Bioorg Med Chem. 2000 May;8(5):843-71. doi: 10.1016/s0968-0896(00)00044-4. Bioorg Med Chem. 2000. PMID: 10881998 Review. No abstract available.

6

The three-dimensional structure of the ternary complex of Corynebacterium glutamicum diaminopimelate dehydrogenase-NADPH-L-2-amino-6-methylene-pimelate.

Cirilli M, Scapin G, Sutherland A, Vederas JC, Blanchard JS. Cirilli M, et al. Among authors: sutherland a. Protein Sci. 2000 Oct;9(10):2034-7. doi: 10.1110/ps.9.10.2034. Protein Sci. 2000. PMID: 11106178 Free PMC article.

The three-dimensional (3D) structure of Corynebacterium glutamicum diaminopimelate D-dehydrogenase in a ternary complex with NADPH and L-2-amino-6-methylene-pimelate has been solved and refined to a resolution of 2.1 A. L-2-Amino-6-methylene-pimelate was rece …

The three-dimensional (3D) structure of Corynebacterium glutamicum diaminopimelate D-dehydrogenase in a ternary complex with NADPH an …

7

Recent advances in the biosynthetic studies of lovastatin.

Sutherland A, Auclair K, Vederas JC. Sutherland A, et al. Curr Opin Drug Discov Devel. 2001 Mar;4(2):229-36. Curr Opin Drug Discov Devel. 2001. PMID: 11378962 Review.

8

Synthesis of probes for the active site of leucine dehydrogenase.

Sutherland A, Willis CL. Sutherland A, et al. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1941-4. doi: 10.1016/s0960-894x(99)00297-8. Bioorg Med Chem Lett. 1999. PMID: 10450958

9

Stille coupling reactions of 4-substituted-2,5-diphenyloxazoles.

Clapham B, Sutherland AJ. Clapham B, et al. Among authors: sutherland aj. J Org Chem. 2001 Dec 28;66(26):9033-7. doi: 10.1021/jo0107150. J Org Chem. 2001. PMID: 11749641 No abstract available.

10

Scintillation proximity assays for the real-time detection and quantification of the progress of reactions upon solid supports.

McCairn MC, Sutherland AJ. McCairn MC, et al. Chem Commun (Camb). 2004 Feb 7;(3):296-7. doi: 10.1039/b313223d. Epub 2004 Jan 5. Chem Commun (Camb). 2004. PMID: 14740045 No abstract available.

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