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Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites.
Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Glenn MP, et al. Among authors: chang sy. J Med Chem. 2006 Sep 21;49(19):5710-27. doi: 10.1021/jm060081v. J Med Chem. 2006. PMID: 16970397 Free PMC article.
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Glenn MP, et al. Among authors: chang sy. Angew Chem Int Ed Engl. 2005 Aug 5;44(31):4903-6. doi: 10.1002/anie.200500674. Angew Chem Int Ed Engl. 2005. PMID: 16007716 No abstract available.
Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents.
Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Fletcher S, et al. Among authors: chang sy. J Med Chem. 2010 Oct 14;53(19):6867-88. doi: 10.1021/jm1001748. J Med Chem. 2010. PMID: 20822181 Free PMC article.
Analysis of yeast protein kinases using protein chips.
Zhu H, Klemic JF, Chang S, Bertone P, Casamayor A, Klemic KG, Smith D, Gerstein M, Reed MA, Snyder M. Zhu H, et al. Nat Genet. 2000 Nov;26(3):283-9. doi: 10.1038/81576. Nat Genet. 2000. PMID: 11062466
Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial.
Ware LB, Files DC, Fowler A, Aboodi MS, Aggarwal NR, Brower RG, Chang SY, Douglas IS, Fields S, Foulkes AS, Ginde AA, Harris ES, Hendey GW, Hite RD, Huang W, Lai P, Liu KD, Thompson BT, Matthay MA; National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network. Ware LB, et al. Among authors: chang sy. JAMA. 2024 May 19. doi: 10.1001/jama.2024.8772. Online ahead of print. JAMA. 2024. PMID: 38762798
1,638 results