Sawabe K - Search Results

1

Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating.

Nakamura K, Koyama Y, Takahashi K, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Sugawara Y, Sawabe K, Ohashi A, Ohnuma T, Arai H, Nishimura H, Hasegawa H, Hirose S. Nakamura K, et al. Among authors: sawabe k. J Mol Biol. 2006 Oct 20;363(2):345-54. doi: 10.1016/j.jmb.2006.08.051. Epub 2006 Aug 25. J Mol Biol. 2006. PMID: 16979184

2

Late developmental stage-specific role of tryptophan hydroxylase 1 in brain serotonin levels.

Nakamura K, Sugawara Y, Sawabe K, Ohashi A, Tsurui H, Xiu Y, Ohtsuji M, Lin QS, Nishimura H, Hasegawa H, Hirose S. Nakamura K, et al. Among authors: sawabe k. J Neurosci. 2006 Jan 11;26(2):530-4. doi: 10.1523/JNEUROSCI.1835-05.2006. J Neurosci. 2006. PMID: 16407550 Free PMC article.

3

Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin.

Sawabe K, Yamamoto K, Harada Y, Ohashi A, Sugawara Y, Matsuoka H, Hasegawa H. Sawabe K, et al. Mol Genet Metab. 2008 Aug;94(4):410-416. doi: 10.1016/j.ymgme.2008.04.007. Epub 2008 Jun 3. Mol Genet Metab. 2008. PMID: 18511317

4

Tetrahydrobiopterin uptake in supplemental administration: elevation of tissue tetrahydrobiopterin in mice following uptake of the exogenously oxidized product 7,8-dihydrobiopterin and subsequent reduction by an anti-folate-sensitive process.

Sawabe K, Wakasugi KO, Hasegawa H. Sawabe K, et al. J Pharmacol Sci. 2004 Oct;96(2):124-33. doi: 10.1254/jphs.fp0040280. Epub 2004 Oct 2. J Pharmacol Sci. 2004. PMID: 15467264 Free article.

5

Accumulated BH4 in mouse liver caused by administration of either 6R- or 6SBH4 consisted solely of the 6R-diastereomer: evidence of oxidation to BH2 and enzymic reduction.

Sawabe K, Suetake Y, Wakasugi KO, Hasegawa H. Sawabe K, et al. Mol Genet Metab. 2005 Dec;86 Suppl 1:S145-7. doi: 10.1016/j.ymgme.2005.06.019. Epub 2005 Sep 13. Mol Genet Metab. 2005. PMID: 16165384

6

Delivery of exogenous tetrahydrobiopterin (BH4) to cells of target organs: role of salvage pathway and uptake of its precursor in effective elevation of tissue BH4.

Hasegawa H, Sawabe K, Nakanishi N, Wakasugi OK. Hasegawa H, et al. Among authors: sawabe k. Mol Genet Metab. 2005 Dec;86 Suppl 1:S2-10. doi: 10.1016/j.ymgme.2005.09.002. Epub 2005 Oct 25. Mol Genet Metab. 2005. PMID: 16256391 Review.

7

Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line.

Iida Y, Sawabe K, Kojima M, Oguro K, Nakanishi N, Hasegawa H. Iida Y, et al. Among authors: sawabe k. Eur J Biochem. 2002 Oct;269(19):4780-8. doi: 10.1046/j.1432-1033.2002.03188.x. Eur J Biochem. 2002. PMID: 12354109 Free article.

We previously demonstrated in mast cell lines RBL2H3 and FMA3 that tryptophan hydroxylase (TPH) undergoes very fast turnover driven by 26S-proteasomes [Kojima, M., Oguro, K., Sawabe, K., Iida, Y., Ikeda, R., Yamashita, A., Nakanishi, N. & Hasegawa, H. (20 …

We previously demonstrated in mast cell lines RBL2H3 and FMA3 that tryptophan hydroxylase (TPH) undergoes very fast turnover driven by 26S-p …

8

Cellular accumulation of tetrahydrobiopterin following its administration is mediated by two different processes; direct uptake and indirect uptake mediated by a methotrexate-sensitive process.

Sawabe K, Suetake Y, Nakanishi N, Wakasugi KO, Hasegawa H. Sawabe K, et al. Mol Genet Metab. 2005 Dec;86 Suppl 1:S133-8. doi: 10.1016/j.ymgme.2005.06.020. Epub 2005 Sep 13. Mol Genet Metab. 2005. PMID: 16165391

9

Transcellular relocation of tetrahydrobiopterin across Caco-2 cells: a model study of tetrahydrobiopterin absorption through epithelial cells of intestinal mucosa.

Ohashi A, Fukumuro M, Sawabe K, Mamada K, Sugawara Y, Matsuoka H, Hasegawa H. Ohashi A, et al. Among authors: sawabe k. J Inherit Metab Dis. 2009 Feb;32(1):73-8. doi: 10.1007/s10545-008-0961-3. Epub 2008 Nov 3. J Inherit Metab Dis. 2009. PMID: 18979179

10

Rapid turnover of tryptophan hydroxylase is driven by proteasomes in RBL2H3 cells, a serotonin producing mast cell line.

Kojima M, Oguro K, Sawabe K, Iida Y, Ikeda R, Yamashita A, Nakanishi N, Hasegawa H. Kojima M, et al. Among authors: sawabe k. J Biochem. 2000 Jan;127(1):121-7. doi: 10.1093/oxfordjournals.jbchem.a022572. J Biochem. 2000. PMID: 10731674 Free article.

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