Mekel MJ - Search Results

1

The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).

Sabat M, VanRens JC, Laufersweiler MJ, Brugel TA, Maier J, Golebiowski A, De B, Easwaran V, Hsieh LC, Walter RL, Mekel MJ, Evdokimov A, Janusz MJ. Sabat M, et al. Among authors: mekel mj. Bioorg Med Chem Lett. 2006 Dec 1;16(23):5973-7. doi: 10.1016/j.bmcl.2006.08.132. Epub 2006 Sep 25. Bioorg Med Chem Lett. 2006. PMID: 16997556

2

Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.

Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Renock S, Xu K, Pokross M, Zhou S, Winter C, Walter R, Mekel M, Evdokimov AG. Warshakoon NC, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5517-22. doi: 10.1016/j.bmcl.2006.08.040. Epub 2006 Aug 22. Bioorg Med Chem Lett. 2006. PMID: 16931007

3

Development of orally bioavailable bicyclic pyrazolones as inhibitors of tumor necrosis factor-alpha production.

Clark MP, Laughlin SK, Laufersweiler MJ, Bookland RG, Brugel TA, Golebiowski A, Sabat MP, Townes JA, VanRens JC, Djung JF, Natchus MG, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Heitmeyer SA, Brown KK, Juergens K, Taiwo YO, Janusz MJ. Clark MP, et al. Among authors: mekel mj. J Med Chem. 2004 May 20;47(11):2724-7. doi: 10.1021/jm049968m. J Med Chem. 2004. PMID: 15139749

4

The development of novel inhibitors of tumor necrosis factor-alpha (TNF-alpha) production based on substituted [5,5]-bicyclic pyrazolones.

Laufersweiler MJ, Brugel TA, Clark MP, Golebiowski A, Bookland RG, Laughlin SK, Sabat MP, Townes JA, VanRens JC, De B, Hsieh LC, Heitmeyer SA, Juergens K, Brown KK, Mekel MJ, Walter RL, Janusz MJ. Laufersweiler MJ, et al. Among authors: mekel mj. Bioorg Med Chem Lett. 2004 Aug 16;14(16):4267-72. doi: 10.1016/j.bmcl.2004.06.001. Bioorg Med Chem Lett. 2004. PMID: 15261284

5

The development of monocyclic pyrazolone based cytokine synthesis inhibitors.

Golebiowski A, Townes JA, Laufersweiler MJ, Brugel TA, Clark MP, Clark CM, Djung JF, Laughlin SK, Sabat MP, Bookland RG, VanRens JC, De B, Hsieh LC, Janusz MJ, Walter RL, Webster ME, Mekel MJ. Golebiowski A, et al. Among authors: mekel mj. Bioorg Med Chem Lett. 2005 May 2;15(9):2285-9. doi: 10.1016/j.bmcl.2005.03.007. Bioorg Med Chem Lett. 2005. PMID: 15837310

6

The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.

Laughlin SK, Clark MP, Djung JF, Golebiowski A, Brugel TA, Sabat M, Bookland RG, Laufersweiler MJ, VanRens JC, Townes JA, De B, Hsieh LC, Xu SC, Walter RL, Mekel MJ, Janusz MJ. Laughlin SK, et al. Among authors: mekel mj. Bioorg Med Chem Lett. 2005 May 2;15(9):2399-403. doi: 10.1016/j.bmcl.2005.02.066. Bioorg Med Chem Lett. 2005. PMID: 15837333

7

Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1.

Brugel TA, Maier JA, Clark MP, Sabat M, Golebiowski A, Bookland RG, Laufersweiler MJ, Laughlin SK, Vanrens JC, De B, Hsieh LC, Mekel MJ, Janusz MJ. Brugel TA, et al. Among authors: mekel mj. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3510-3. doi: 10.1016/j.bmcl.2006.03.095. Epub 2006 May 2. Bioorg Med Chem Lett. 2006. PMID: 16632356

8

The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.

Sabat M, Vanrens JC, Clark MP, Brugel TA, Maier J, Bookland RG, Laufersweiler MJ, Laughlin SK, Golebiowski A, De B, Hsieh LC, Walter RL, Mekel MJ, Janusz MJ. Sabat M, et al. Among authors: mekel mj. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4360-5. doi: 10.1016/j.bmcl.2006.05.050. Epub 2006 Jun 5. Bioorg Med Chem Lett. 2006. PMID: 16750367

9

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors.

Warshakoon NC, Wu S, Boyer A, Kawamoto R, Renock S, Xu K, Pokross M, Evdokimov AG, Zhou S, Winter C, Walter R, Mekel M. Warshakoon NC, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5687-90. doi: 10.1016/j.bmcl.2006.08.017. Bioorg Med Chem Lett. 2006. PMID: 16908145

10

Design and synthesis of substituted pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.

Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Bhatt RT, Renock S, Xu K, Pokross M, Zhou S, Walter R, Mekel M, Evdokimov AG, East S. Warshakoon NC, et al. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5616-20. doi: 10.1016/j.bmcl.2006.08.026. Bioorg Med Chem Lett. 2006. PMID: 16908149

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