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Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.
Vasireddy V, Uchida Y, Salem N Jr, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R. Vasireddy V, et al. Among authors: kim sy. Hum Mol Genet. 2007 Mar 1;16(5):471-82. doi: 10.1093/hmg/ddl480. Epub 2007 Jan 5. Hum Mol Genet. 2007. PMID: 17208947 Free PMC article.
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