Bruns RF - Search Results

1

Azetidinones as vasopressin V1a antagonists.

Guillon CD, Koppel GA, Brownstein MJ, Chaney MO, Ferris CF, Lu SF, Fabio KM, Miller MJ, Heindel ND, Hunden DC, Cooper RD, Kaldor SW, Skelton JJ, Dressman BA, Clay MP, Steinberg MI, Bruns RF, Simon NG. Guillon CD, et al. Among authors: bruns rf. Bioorg Med Chem. 2007 Mar 1;15(5):2054-80. doi: 10.1016/j.bmc.2006.12.031. Epub 2006 Dec 23. Bioorg Med Chem. 2007. PMID: 17234419 Free PMC article.

2

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor.

Hao J, Beck JP, Schaus JM, Krushinski JH, Chen Q, Beadle CD, Vidal P, Reinhard MR, Dressman BA, Massey SM, Boulet SL, Cohen MP, Watson BM, Tupper D, Gardinier KM, Myers J, Johansson AM, Richardson J, Richards DS, Hembre EJ, Remick DM, Coates DA, Bhardwaj RM, Diseroad BA, Bender D, Stephenson G, Wolfangel CD, Diaz N, Getman BG, Wang XS, Heinz BA, Cramer JW, Zhou X, Maren DL, Falcone JF, Wright RA, Mitchell SN, Carter G, Yang CR, Bruns RF, Svensson KA. Hao J, et al. Among authors: bruns rf. J Med Chem. 2019 Oct 10;62(19):8711-8732. doi: 10.1021/acs.jmedchem.9b01234. Epub 2019 Sep 30. J Med Chem. 2019. PMID: 31532644

3

Linear and proximal benzo-separated alkylated xanthines as adenosine-receptor antagonists.

Schneller SW, Ibay AC, Christ WJ, Bruns RF. Schneller SW, et al. Among authors: bruns rf. J Med Chem. 1989 Oct;32(10):2247-54. doi: 10.1021/jm00130a004. J Med Chem. 1989. PMID: 2795597

4

Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists.

Zarrinmayeh H, Zimmerman DM, Cantrell BE, Schober DA, Bruns RF, Gackenheimer SL, Ornstein PL, Hipskind PA, Britton TC, Gehlert DR. Zarrinmayeh H, et al. Among authors: bruns rf. Bioorg Med Chem Lett. 1999 Mar 8;9(5):647-52. doi: 10.1016/s0960-894x(99)00082-7. Bioorg Med Chem Lett. 1999. PMID: 10201822

5

3-Aryl-1,2-diacetamidopropane derivatives as novel and potent NK-1 receptor antagonists.

Hipskind PA, Howbert JJ, Bruns RF, Cho SS, Crowell TA, Foreman MM, Gehlert DR, Iyengar S, Johnson KW, Krushinski JH, Li DL, Lobb KL, Mason NR, Muehl BS, Nixon JA, Phebus LA, Regoli D, Simmons RM, Threlkeld PG, Waters DC, Gitter BD. Hipskind PA, et al. Among authors: bruns rf. J Med Chem. 1996 Feb 2;39(3):736-48. doi: 10.1021/jm950616c. J Med Chem. 1996. PMID: 8576917

6

[1,2,4]Triazolo[4,3-a]quinoxalin-4-amines: a new class of A1 receptor selective adenosine antagonists.

Trivedi BK, Bruns RF. Trivedi BK, et al. Among authors: bruns rf. J Med Chem. 1988 May;31(5):1011-4. doi: 10.1021/jm00400a021. J Med Chem. 1988. PMID: 3361571

7

Structure-activity relationships of a series of 1-substituted-4-methylbenzimidazole neuropeptide Y-1 receptor antagonists.

Zimmerman DM, Cantrell BE, Smith EC, Nixon JA, Bruns RF, Gitter B, Hipskind PA, Ornstein PL, Zarrinmayeh H, Britton TC, Schober DA, Gehlert DR. Zimmerman DM, et al. Among authors: bruns rf. Bioorg Med Chem Lett. 1998 Mar 3;8(5):473-6. doi: 10.1016/s0960-894x(98)00048-1. Bioorg Med Chem Lett. 1998. PMID: 9871601

8

Synthesis of xanthines as adenosine antagonists, a practical quantitative structure-activity relationship application.

Hamilton HW, Ortwine DF, Worth DF, Badger EW, Bristol JA, Bruns RF, Haleen SJ, Steffen RP. Hamilton HW, et al. Among authors: bruns rf. J Med Chem. 1985 Aug;28(8):1071-9. doi: 10.1021/jm00146a016. J Med Chem. 1985. PMID: 2991519

9

Structure-activity relationships of a series of benzothiophene-derived NPY Y1 antagonists: optimization of the C-2 side chain.

Britton TC, Spinazze PG, Hipskind PA, Zimmerman DM, Zarrinmayeh H, Schober DA, Gehlert DR, Bruns RF. Britton TC, et al. Among authors: bruns rf. Bioorg Med Chem Lett. 1999 Feb 8;9(3):475-80. doi: 10.1016/s0960-894x(99)00019-0. Bioorg Med Chem Lett. 1999. PMID: 10091705

10

Evaluation and synthesis of aminohydroxyisoxazoles and pyrazoles as potential glycine agonists.

Drummond J, Johnson G, Nickell DG, Ortwine DF, Bruns RF, Welbaum B. Drummond J, et al. Among authors: bruns rf. J Med Chem. 1989 Sep;32(9):2116-28. doi: 10.1021/jm00129a016. J Med Chem. 1989. PMID: 2549245

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