Hobbs DW - Search Results

1

Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists.

Guo T, Gu H, Hobbs DW, Busler DE, Rokosz LL. Guo T, et al. Among authors: hobbs dw. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1718-21. doi: 10.1016/j.bmcl.2006.12.080. Epub 2006 Dec 24. Bioorg Med Chem Lett. 2007. PMID: 17251014

2

Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis.

Guo T, Hunter RC, Gu H, Rokosz LL, Stauffer TM, Hobbs DW. Guo T, et al. Among authors: hobbs dw. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3691-5. doi: 10.1016/j.bmcl.2005.05.039. Bioorg Med Chem Lett. 2005. PMID: 15953726

3

Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis.

Guo T, Shao Y, Qian G, Rokosz LL, Stauffer TM, Hunter RC, Babu SD, Gu H, Hobbs DW. Guo T, et al. Among authors: hobbs dw. Bioorg Med Chem Lett. 2005 Aug 15;15(16):3696-700. doi: 10.1016/j.bmcl.2005.05.085. Bioorg Med Chem Lett. 2005. PMID: 15978811

4

Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.

Guo T, Gu H, Hobbs DW, Rokosz LL, Stauffer TM, Jacob B, Clader JW. Guo T, et al. Among authors: hobbs dw. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3010-3. doi: 10.1016/j.bmcl.2007.03.055. Epub 2007 Mar 23. Bioorg Med Chem Lett. 2007. PMID: 17418571

5

Preparation of encoded combinatorial libraries for drug discovery.

Guo T, Hobbs DW. Guo T, et al. Among authors: hobbs dw. Methods Mol Biol. 2002;201:23-39. doi: 10.1385/1-59259-285-6:23. Methods Mol Biol. 2002. PMID: 12357930 No abstract available.

6

Privileged structure-based combinatorial libraries targeting G protein-coupled receptors.

Guo T, Hobbs DW. Guo T, et al. Among authors: hobbs dw. Assay Drug Dev Technol. 2003 Aug;1(4):579-92. doi: 10.1089/154065803322302835. Assay Drug Dev Technol. 2003. PMID: 15090254

7

Development of BACE1 inhibitors for Alzheimer's disease.

Guo T, Hobbs DW. Guo T, et al. Among authors: hobbs dw. Curr Med Chem. 2006;13(15):1811-29. doi: 10.2174/092986706777452489. Curr Med Chem. 2006. PMID: 16787223 Review.

8

Library design concepts and implementation strategies.

Hobbs DW, Guo T. Hobbs DW, et al. J Recept Signal Transduct Res. 2001 Nov;21(4):311-56. doi: 10.1081/rrs-100107922. J Recept Signal Transduct Res. 2001. PMID: 11789688 Review. No abstract available.

9

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.

Cumming JN, Le TX, Babu S, Carroll C, Chen X, Favreau L, Gaspari P, Guo T, Hobbs DW, Huang Y, Iserloh U, Kennedy ME, Kuvelkar R, Li G, Lowrie J, McHugh NA, Ozgur L, Pan J, Parker EM, Saionz K, Stamford AW, Strickland C, Tadesse D, Voigt J, Wang L, Wu Y, Zhang L, Zhang Q. Cumming JN, et al. Among authors: hobbs dw. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3236-41. doi: 10.1016/j.bmcl.2008.04.050. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18468890

10

III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl-piperazinyl-piperidine scaffold.

Kim SH, Anilkumar GN, Zawacki LG, Zeng Q, Yang DY, Shao Y, Dong G, Xu X, Yu W, Jiang Y, Jenh CH, Hall JW 3rd, Carroll CD, Hobbs DW, Baldwin JJ, McGuinness BF, Rosenblum SB, Kozlowski JA, Shankar BB, Shih NY. Kim SH, et al. Among authors: hobbs dw. Bioorg Med Chem Lett. 2011 Dec 1;21(23):6982-6. doi: 10.1016/j.bmcl.2011.09.120. Epub 2011 Oct 5. Bioorg Med Chem Lett. 2011. PMID: 22018463

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