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A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release.
Chu ZL, Carroll C, Alfonso J, Gutierrez V, He H, Lucman A, Pedraza M, Mondala H, Gao H, Bagnol D, Chen R, Jones RM, Behan DP, Leonard J. Chu ZL, et al. Among authors: carroll c. Endocrinology. 2008 May;149(5):2038-47. doi: 10.1210/en.2007-0966. Epub 2008 Jan 17. Endocrinology. 2008. PMID: 18202141
Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119.
Semple G, Fioravanti B, Pereira G, Calderon I, Uy J, Choi K, Xiong Y, Ren A, Morgan M, Dave V, Thomsen W, Unett DJ, Xing C, Bossie S, Carroll C, Chu ZL, Grottick AJ, Hauser EK, Leonard J, Jones RM. Semple G, et al. Among authors: carroll c. J Med Chem. 2008 Sep 11;51(17):5172-5. doi: 10.1021/jm8006867. Epub 2008 Aug 13. J Med Chem. 2008. PMID: 18698756
N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.
Chu ZL, Carroll C, Chen R, Alfonso J, Gutierrez V, He H, Lucman A, Xing C, Sebring K, Zhou J, Wagner B, Unett D, Jones RM, Behan DP, Leonard J. Chu ZL, et al. Among authors: carroll c. Mol Endocrinol. 2010 Jan;24(1):161-70. doi: 10.1210/me.2009-0239. Epub 2009 Nov 9. Mol Endocrinol. 2010. PMID: 19901198 Free PMC article.
Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series.
Han S, Narayanan S, Kim SH, Calderon I, Zhu X, Kawasaki A, Yue D, Lehmann J, Wong A, Buzard DJ, Semple G, Carroll C, Chu ZL, Al-Sharmma H, Shu HH, Tung SF, Unett DJ, Behan DP, Yoon WH, Morgan M, Usmani KA, Chen C, Sadeque A, Leonard JN, Jones RM. Han S, et al. Among authors: carroll c. Bioorg Med Chem Lett. 2015 Aug 1;25(15):3034-8. doi: 10.1016/j.bmcl.2015.04.102. Epub 2015 May 23. Bioorg Med Chem Lett. 2015. PMID: 26048791
Synthesis and cytotoxicity of novel sansalvamide A derivatives.
Carroll CL, Johnston JV, Kekec A, Brown JD, Parry E, Cajica J, Medina I, Cook KM, Corral R, Pan PS, McAlpine SR. Carroll CL, et al. Org Lett. 2005 Aug 4;7(16):3481-4. doi: 10.1021/ol051161g. Org Lett. 2005. PMID: 16048322
1,221 results