Troxler T - Search Results

1

Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists.

Troxler T, Hoyer D, Langenegger D, Neumann P, Pfäffli P, Schoeffter P, Sorg D, Swoboda R, Hurth K. Troxler T, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3983-7. doi: 10.1016/j.bmcl.2007.04.086. Epub 2007 Apr 29. Bioorg Med Chem Lett. 2007. PMID: 17507221

2

SRA880, in vitro characterization of the first non-peptide somatostatin sst(1) receptor antagonist.

Hoyer D, Nunn C, Hannon J, Schoeffter P, Feuerbach D, Schuepbach E, Langenegger D, Bouhelal R, Hurth K, Neumann P, Troxler T, Pfaeffli P. Hoyer D, et al. Among authors: troxler t. Neurosci Lett. 2004 May 6;361(1-3):132-5. doi: 10.1016/j.neulet.2004.02.017. Neurosci Lett. 2004. PMID: 15135911

3

Drug design at peptide receptors: somatostatin receptor ligands.

Hannon JP, Nunn C, Stolz B, Bruns C, Weckbecker G, Lewis I, Troxler T, Hurth K, Hoyer D. Hannon JP, et al. Among authors: troxler t. J Mol Neurosci. 2002 Feb-Apr;18(1-2):15-27. doi: 10.1385/JMN:18:1-2:15. J Mol Neurosci. 2002. PMID: 11931345 Review.

4

SAR of the arylpiperazine moiety of obeline somatostatin sst1 receptor antagonists.

Hurth K, Enz A, Floersheim P, Gentsch C, Hoyer D, Langenegger D, Neumann P, Pfäffli P, Sorg D, Swoboda R, Vassout A, Troxler T. Hurth K, et al. Among authors: troxler t. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3988-91. doi: 10.1016/j.bmcl.2007.04.078. Epub 2007 Apr 30. Bioorg Med Chem Lett. 2007. PMID: 17512199

5

Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst 1 receptor.

Troxler T, Enz A, Hoyer D, Langenegger D, Neumann P, Pfäffli P, Schoeffter P, Hurth K. Troxler T, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):979-82. doi: 10.1016/j.bmcl.2007.12.030. Epub 2007 Dec 26. Bioorg Med Chem Lett. 2008. PMID: 18162395

6

Discovery of novel non-peptidic beta-alanine piperazine amide derivatives and their optimization to achiral, easily accessible, potent and selective somatostatin sst1 receptor antagonists.

Troxler T, Hurth K, Mattes H, Prashad M, Schoeffter P, Langenegger D, Enz A, Hoyer D. Troxler T, et al. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1305-9. doi: 10.1016/j.bmcl.2009.01.072. Epub 2009 Jan 27. Bioorg Med Chem Lett. 2009. PMID: 19208473

7

Decahydroisoquinoline derivatives as novel non-peptidic, potent and subtype-selective somatostatin sst(3) receptor antagonists.

Troxler T, Hurth K, Schuh KH, Schoeffter P, Langenegger D, Enz A, Hoyer D. Troxler T, et al. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1728-34. doi: 10.1016/j.bmcl.2010.01.063. Epub 2010 Jan 21. Bioorg Med Chem Lett. 2010. PMID: 20137944

8

Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity.

Spanka C, Glatthar R, Desrayaud S, Fendt M, Orain D, Troxler T, Vranesic I. Spanka C, et al. Among authors: troxler t. Bioorg Med Chem Lett. 2010 Jan 1;20(1):184-8. doi: 10.1016/j.bmcl.2009.11.001. Epub 2009 Nov 5. Bioorg Med Chem Lett. 2010. PMID: 19931453

9

Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2.

Troxler T, Greenidge P, Zimmermann K, Desrayaud S, Drückes P, Schweizer T, Stauffer D, Rovelli G, Shimshek DR. Troxler T, et al. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4085-90. doi: 10.1016/j.bmcl.2013.05.054. Epub 2013 May 24. Bioorg Med Chem Lett. 2013. PMID: 23768909

10

Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors.

Glatthar R, Stojanovic A, Troxler T, Mattes H, Möbitz H, Beerli R, Blanz J, Gassmann E, Drückes P, Fendrich G, Gutmann S, Martiny-Baron G, Spence F, Hornfeld J, Peel JE, Sparrer H. Glatthar R, et al. Among authors: troxler t. J Med Chem. 2016 Aug 25;59(16):7544-60. doi: 10.1021/acs.jmedchem.6b00598. Epub 2016 Aug 17. J Med Chem. 2016. PMID: 27502541

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