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Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Buckbinder L, Crawford DT, Qi H, Ke HZ, Olson LM, Long KR, Bonnette PC, Baumann AP, Hambor JE, Grasser WA 3rd, Pan LC, Owen TA, Luzzio MJ, Hulford CA, Gebhard DF, Paralkar VM, Simmons HA, Kath JC, Roberts WG, Smock SL, Guzman-Perez A, Brown TA, Li M. Buckbinder L, et al. Among authors: paralkar vm. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10619-24. doi: 10.1073/pnas.0701421104. Epub 2007 May 30. Proc Natl Acad Sci U S A. 2007. PMID: 17537919 Free PMC article.
An EP2 receptor-selective prostaglandin E2 agonist induces bone healing.
Paralkar VM, Borovecki F, Ke HZ, Cameron KO, Lefker B, Grasser WA, Owen TA, Li M, DaSilva-Jardine P, Zhou M, Dunn RL, Dumont F, Korsmeyer R, Krasney P, Brown TA, Plowchalk D, Vukicevic S, Thompson DD. Paralkar VM, et al. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6736-40. doi: 10.1073/pnas.1037343100. Epub 2003 May 14. Proc Natl Acad Sci U S A. 2003. PMID: 12748385 Free PMC article.
Prostaglandin E(2) receptors in bone formation.
Li M, Thompson DD, Paralkar VM. Li M, et al. Among authors: paralkar vm. Int Orthop. 2007 Dec;31(6):767-72. doi: 10.1007/s00264-007-0406-x. Epub 2007 Jun 26. Int Orthop. 2007. PMID: 17593365 Free PMC article. Review.
Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models.
Ke HZ, Paralkar VM, Grasser WA, Crawford DT, Qi H, Simmons HA, Pirie CM, Chidsey-Frink KL, Owen TA, Smock SL, Chen HK, Jee WS, Cameron KO, Rosati RL, Brown TA, Dasilva-Jardine P, Thompson DD. Ke HZ, et al. Among authors: paralkar vm. Endocrinology. 1998 Apr;139(4):2068-76. doi: 10.1210/endo.139.4.5902. Endocrinology. 1998. PMID: 9528995
Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats.
Cameron KO, Lefker BA, Chu-Moyer MY, Crawford DT, Jardine PD, DeNinno SL, Gilbert S, Grasser WA, Ke H, Lu B, Owen TA, Paralkar VM, Qi H, Scott DO, Thompson DD, Tjoa CM, Zawistoski MP. Cameron KO, et al. Among authors: paralkar vm. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1799-802. doi: 10.1016/j.bmcl.2006.01.018. Epub 2006 Jan 26. Bioorg Med Chem Lett. 2006. PMID: 16442794
A nonprostanoid EP4 receptor selective prostaglandin E2 agonist restores bone mass and strength in aged, ovariectomized rats.
Ke HZ, Crawford DT, Qi H, Simmons HA, Owen TA, Paralkar VM, Li M, Lu B, Grasser WA, Cameron KO, Lefker BA, DaSilva-Jardine P, Scott DO, Zhang Q, Tian XY, Jee WS, Brown TA, Thompson DD. Ke HZ, et al. Among authors: paralkar vm. J Bone Miner Res. 2006 Apr;21(4):565-75. doi: 10.1359/jbmr.051110. Epub 2006 Apr 5. J Bone Miner Res. 2006. PMID: 16598377 Free article.
47 results