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Page 1
Metabolism-based identification of a potent thrombin receptor antagonist.
Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee W, Kao G, Lin Y, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Foster C, Smith-Torhan A, Alton K, Bryant M, Hsieh Y, Lau J, Palamanda J. Clasby MC, et al. Among authors: eagen k. J Med Chem. 2007 Jan 11;50(1):129-38. doi: 10.1021/jm061043e. J Med Chem. 2007. PMID: 17201416
Himbacine derived thrombin receptor antagonists: discovery of a new tricyclic core.
Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Lin Y, Tagat JR, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Hsieh Y, McPhail AT. Clasby MC, et al. Among authors: eagen k. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3647-51. doi: 10.1016/j.bmcl.2007.04.061. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17490877
Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring.
Xia Y, Chackalamannil S, Clasby M, Doller D, Eagen K, Greenlee WJ, Tsai H, Agans-Fantuzzi J, Ahn HS, Boykow GC, Hsieh Y, Lunn CA, Chintala M. Xia Y, et al. Among authors: eagen k. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4509-13. doi: 10.1016/j.bmcl.2007.06.002. Epub 2007 Jun 15. Bioorg Med Chem Lett. 2007. PMID: 17574850
Discovery of nor-seco himbacine analogs as thrombin receptor antagonists.
Chelliah MV, Chackalamannil S, Xia Y, Eagen K, Greenlee WJ, Ahn HS, Agans-Fantuzzi J, Boykow G, Hsieh Y, Bryant M, Chan TM, Chintala M. Chelliah MV, et al. Among authors: eagen k. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2544-9. doi: 10.1016/j.bmcl.2012.01.138. Epub 2012 Feb 16. Bioorg Med Chem Lett. 2012. PMID: 22405832
Himbacine-derived thrombin receptor antagonists: c7-spirocyclic analogues of vorapaxar.
Chelliah MV, Eagen K, Guo Z, Chackalamannil S, Xia Y, Tsai H, Greenlee WJ, Ahn HS, Kurowski S, Boykow G, Hsieh Y, Chintala M. Chelliah MV, et al. Among authors: eagen k. ACS Med Chem Lett. 2014 Mar 11;5(5):561-5. doi: 10.1021/ml500008w. eCollection 2014 May 8. ACS Med Chem Lett. 2014. PMID: 24900880 Free PMC article.
Potent, low molecular weight thrombin receptor antagonists.
Chackalamannil S, Doller D, Eagen K, Czarniecki M, Ahn HS, Foster CJ, Boykow G. Chackalamannil S, et al. Among authors: eagen k. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2851-3. doi: 10.1016/s0960-894x(01)00555-8. Bioorg Med Chem Lett. 2001. PMID: 11597414
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.
Neelamkavil SF, Agrawal S, Bara T, Bennett C, Bhat S, Biswas D, Brockunier L, Buist N, Burnette D, Cartwright M, Chackalamannil S, Chase R, Chelliah M, Chen A, Clasby M, Colandrea VJ, Davies IW, Eagen K, Guo Z, Han Y, Howe J, Jayne C, Josien H, Kargman S, Marcantonio K, Miao S, Miller R, Nolting A, Pinto P, Rajagopalan M, Ruck RT, Shah U, Soriano A, Sperbeck D, Velazquez F, Wu J, Xia Y, Venkatraman S. Neelamkavil SF, et al. Among authors: eagen k. ACS Med Chem Lett. 2015 Dec 22;7(1):111-6. doi: 10.1021/acsmedchemlett.5b00425. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819676 Free PMC article.
51 results