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Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS, Martinelli GJ, Mitchell PG, Laird ER, Liras JL, Lopresti-Morrow LL, Pandit J, Reilly UD, Robertson D, Vaughn-Bowser ML, Wolf-Gouviea LA, Yocum SA. Freeman-Cook KD, et al. Among authors: datta k. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6529-34. doi: 10.1016/j.bmcl.2007.09.085. Epub 2007 Sep 29. Bioorg Med Chem Lett. 2007. PMID: 17935984
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robertson D, Sperger D, Vaughn-Bowser ML, Waller DM, Yocum SA. Reiter LA, et al. Among authors: datta k. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5822-6. doi: 10.1016/j.bmcl.2006.08.066. Epub 2006 Aug 30. Bioorg Med Chem Lett. 2006. PMID: 16942871
Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
Johnson AR, Pavlovsky AG, Ortwine DF, Prior F, Man CF, Bornemeier DA, Banotai CA, Mueller WT, McConnell P, Yan C, Baragi V, Lesch C, Roark WH, Wilson M, Datta K, Guzman R, Han HK, Dyer RD. Johnson AR, et al. Among authors: datta k. J Biol Chem. 2007 Sep 21;282(38):27781-91. doi: 10.1074/jbc.M703286200. Epub 2007 Jul 10. J Biol Chem. 2007. PMID: 17623656 Free article.
Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute.
Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K. Miousse IR, et al. Among authors: datta k. Toxicology. 2015 Sep 1;335:11-9. doi: 10.1016/j.tox.2015.06.009. Epub 2015 Jun 29. Toxicology. 2015. PMID: 26134581 Free article.
705 results