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8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.
J Med Chem. 2007 Dec 27;50(26):6450-3. doi: 10.1021/jm701280z. Epub 2007 Dec 1.
J Med Chem. 2007.
PMID: 18052023
(R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors.
Thomas L, Eckhardt M, Langkopf E, Tadayyon M, Himmelsbach F, Mark M.
Thomas L, et al. Among authors: langkopf e.
J Pharmacol Exp Ther. 2008 Apr;325(1):175-82. doi: 10.1124/jpet.107.135723. Epub 2008 Jan 25.
J Pharmacol Exp Ther. 2008.
PMID: 18223196
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3,5-Dihydro-imidazo[4,5-d]pyridazin-4-ones: a class of potent DPP-4 inhibitors.
Eckhardt M, Hauel N, Himmelsbach F, Langkopf E, Nar H, Mark M, Tadayyon M, Thomas L, Guth B, Lotz R.
Eckhardt M, et al. Among authors: langkopf e.
Bioorg Med Chem Lett. 2008 Jun 1;18(11):3158-62. doi: 10.1016/j.bmcl.2008.04.075. Epub 2008 May 1.
Bioorg Med Chem Lett. 2008.
PMID: 18485703
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Inhibition of epidermal growth factor receptor activity by two pyrimidopyrimidine derivatives.
Solca FF, Baum A, Langkopf E, Dahmann G, Heider KH, Himmelsbach F, van Meel JC.
Solca FF, et al. Among authors: langkopf e.
J Pharmacol Exp Ther. 2004 Nov;311(2):502-9. doi: 10.1124/jpet.104.069138. Epub 2004 Jun 15.
J Pharmacol Exp Ther. 2004.
PMID: 15199094
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Molecular recognition of the protein phosphatase 1 glycogen targeting subunit by glycogen phosphorylase.
Pautsch A, Stadler N, Wissdorf O, Langkopf E, Moreth W, Streicher R.
Pautsch A, et al. Among authors: langkopf e.
J Biol Chem. 2008 Apr 4;283(14):8913-8. doi: 10.1074/jbc.M706612200. Epub 2008 Jan 15.
J Biol Chem. 2008.
PMID: 18198182
Free article.
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beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition.
Eger A, Stockinger A, Park J, Langkopf E, Mikula M, Gotzmann J, Mikulits W, Beug H, Foisner R.
Eger A, et al. Among authors: langkopf e.
Oncogene. 2004 Apr 8;23(15):2672-2680. doi: 10.1038/sj.onc.1207416.
Oncogene. 2004.
PMID: 14755243
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