Potter PM - Search Results

1

Identification of human intestinal carboxylesterase as the primary enzyme for activation of a doxazolidine carbamate prodrug.

Barthel BL, Torres RC, Hyatt JL, Edwards CC, Hatfield MJ, Potter PM, Koch TH. Barthel BL, et al. Among authors: potter pm. J Med Chem. 2008 Jan 24;51(2):298-304. doi: 10.1021/jm7011479. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173233

2

Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity.

Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. Among authors: potter pm. Mol Pharmacol. 2004 Jun;65(6):1336-43. doi: 10.1124/mol.65.6.1336. Mol Pharmacol. 2004. PMID: 15155827

3

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Wadkins RM, Hyatt JL, Wei X, Yoon KJ, Wierdl M, Edwards CC, Morton CL, Obenauer JC, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. Among authors: potter pm. J Med Chem. 2005 Apr 21;48(8):2906-15. doi: 10.1021/jm049011j. J Med Chem. 2005. PMID: 15828829

4

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt JL, Moak T, Hatfield MJ, Tsurkan L, Edwards CC, Wierdl M, Danks MK, Wadkins RM, Potter PM. Hyatt JL, et al. Among authors: potter pm. J Med Chem. 2007 Apr 19;50(8):1876-85. doi: 10.1021/jm061471k. Epub 2007 Mar 23. J Med Chem. 2007. PMID: 17378546

5

Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.

Hyatt JL, Wadkins RM, Tsurkan L, Hicks LD, Hatfield MJ, Edwards CC, Ross CR 2nd, Cantalupo SA, Crundwell G, Danks MK, Guy RK, Potter PM. Hyatt JL, et al. Among authors: potter pm. J Med Chem. 2007 Nov 15;50(23):5727-34. doi: 10.1021/jm0706867. Epub 2007 Oct 17. J Med Chem. 2007. PMID: 17941623

6

Improved, selective, human intestinal carboxylesterase inhibitors designed to modulate 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Irinotecan; CPT-11) toxicity.

Hicks LD, Hyatt JL, Stoddard S, Tsurkan L, Edwards CC, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: potter pm. J Med Chem. 2009 Jun 25;52(12):3742-52. doi: 10.1021/jm9001296. J Med Chem. 2009. PMID: 19534556 Free PMC article.

7

Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.

Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR. Fleming CD, et al. Among authors: potter pm. J Mol Biol. 2005 Sep 9;352(1):165-77. doi: 10.1016/j.jmb.2005.07.016. J Mol Biol. 2005. PMID: 16081098

8

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt JL, Stacy V, Wadkins RM, Yoon KJ, Wierdl M, Edwards CC, Zeller M, Hunter AD, Danks MK, Crundwell G, Potter PM. Hyatt JL, et al. Among authors: potter pm. J Med Chem. 2005 Aug 25;48(17):5543-50. doi: 10.1021/jm0504196. J Med Chem. 2005. PMID: 16107154

9

Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds.

Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. Wadkins RM, et al. Among authors: potter pm. Mol Pharmacol. 2007 Mar;71(3):713-23. doi: 10.1124/mol.105.021683. Epub 2006 Dec 13. Mol Pharmacol. 2007. PMID: 17167034

10

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks LD, Hyatt JL, Moak T, Edwards CC, Tsurkan L, Wierdl M, Ferreira AM, Wadkins RM, Potter PM. Hicks LD, et al. Among authors: potter pm. Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. doi: 10.1016/j.bmc.2007.03.012. Epub 2007 Mar 12. Bioorg Med Chem. 2007. PMID: 17399985 Free PMC article.

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