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Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity.
Hess S, Linde Y, Ovadia O, Safrai E, Shalev DE, Swed A, Halbfinger E, Lapidot T, Winkler I, Gabinet Y, Faier A, Yarden D, Xiang Z, Portillo FP, Haskell-Luevano C, Gilon C, Hoffman A. Hess S, et al. Among authors: portillo fp. J Med Chem. 2008 Feb 28;51(4):1026-34. doi: 10.1021/jm701093y. Epub 2008 Jan 26. J Med Chem. 2008. PMID: 18220330
Semi-rigid tripeptide agonists of melanocortin receptors.
Ruwe AR, Koikov L, Abdel-Malek Z, Haskell-Luevano C, Dirain ML, Portillo F, Xiang Z, Wortman M, Knittel JJ. Ruwe AR, et al. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5176-81. doi: 10.1016/j.bmcl.2009.07.025. Epub 2009 Jul 9. Bioorg Med Chem Lett. 2009. PMID: 19635667 Free PMC article.
Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.
Ericson MD, Haslach EM, Schnell SM, Freeman KT, Xiang ZM, Portillo FP, Speth R, Litherland SA, Haskell-Luevano C. Ericson MD, et al. Among authors: portillo fp. ACS Chem Neurosci. 2021 Feb 3;12(3):542-556. doi: 10.1021/acschemneuro.0c00755. Epub 2021 Jan 20. ACS Chem Neurosci. 2021. PMID: 33470098 Free PMC article.