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The 1,4-benzodiazepine-2,5-dione small molecule template results in melanocortin receptor agonists with nanomolar potencies.
J Med Chem. 2008 Mar 13;51(5):1423-31. doi: 10.1021/jm701303z. Epub 2008 Feb 14.
J Med Chem. 2008.
PMID: 18271518
Peptide and small molecules rescue the functional activity and agonist potency of dysfunctional human melanocortin-4 receptor polymorphisms.
Xiang Z, Pogozheva ID, Sorenson NB, Wilczynski AM, Holder JR, Litherland SA, Millard WJ, Mosberg HI, Haskell-Luevano C.
Xiang Z, et al. Among authors: sorenson nb.
Biochemistry. 2007 Jul 17;46(28):8273-87. doi: 10.1021/bi7007382. Epub 2007 Jun 23.
Biochemistry. 2007.
PMID: 17590021
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The melanocortin pathway: effects of voluntary exercise on the melanocortin-4 receptor knockout mice and ACTH(1-24) ligand structure activity relationships at the melanocortin-2 receptor.
Haskell-Luevano C, Todorovic A, Gridley K, Sorenson N, Irani B, Xiang Z.
Haskell-Luevano C, et al.
Endocr Res. 2004 Nov;30(4):591-7. doi: 10.1081/erc-200043759.
Endocr Res. 2004.
PMID: 15666796
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Discovery of a ligand that compensates for decreased endogenous agonist potency of melanocortin-4 receptor polymorphisms identified in obese humans.
Haskell-Luevano C, Xiang Z, Wilczynski AM, Haskell KR, Andreasen AM, Litherland SA, Millard WJ, Pogozheva ID, Mosberg HI, Sorenson NB.
Haskell-Luevano C, et al. Among authors: sorenson nb.
Adv Exp Med Biol. 2009;611:509-10. doi: 10.1007/978-0-387-73657-0_221.
Adv Exp Med Biol. 2009.
PMID: 19400288
No abstract available.
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Aza-scanning of the potent melanocortin receptor agonist Ac-His-D-Phe-Arg-Trp-NH.
Boeglin D, Xiang Z, Sorenson NB, Wood MS, Haskell-Luevano C, Lubell WD.
Boeglin D, et al. Among authors: sorenson nb.
Chem Biol Drug Des. 2006 Apr;67(4):275-83. doi: 10.1111/j.1747-0285.2006.00378.x.
Chem Biol Drug Des. 2006.
PMID: 16629825
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