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VEGF 165 b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy.
Varey AH, Rennel ES, Qiu Y, Bevan HS, Perrin RM, Raffy S, Dixon AR, Paraskeva C, Zaccheo O, Hassan AB, Harper SJ, Bates DO. Varey AH, et al. Among authors: qiu y. Br J Cancer. 2008 Apr 22;98(8):1366-79. doi: 10.1038/sj.bjc.6604308. Epub 2008 Mar 18. Br J Cancer. 2008. PMID: 18349829 Free PMC article.
VEGF165b, an inhibitory vascular endothelial growth factor splice variant: mechanism of action, in vivo effect on angiogenesis and endogenous protein expression.
Woolard J, Wang WY, Bevan HS, Qiu Y, Morbidelli L, Pritchard-Jones RO, Cui TG, Sugiono M, Waine E, Perrin R, Foster R, Digby-Bell J, Shields JD, Whittles CE, Mushens RE, Gillatt DA, Ziche M, Harper SJ, Bates DO. Woolard J, et al. Among authors: qiu y. Cancer Res. 2004 Nov 1;64(21):7822-35. doi: 10.1158/0008-5472.CAN-04-0934. Cancer Res. 2004. PMID: 15520188
Recombinant human VEGF165b inhibits experimental choroidal neovascularization.
Hua J, Spee C, Kase S, Rennel ES, Magnussen AL, Qiu Y, Varey A, Dhayade S, Churchill AJ, Harper SJ, Bates DO, Hinton DR. Hua J, et al. Among authors: qiu y. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4282-8. doi: 10.1167/iovs.09-4360. Epub 2010 Mar 17. Invest Ophthalmol Vis Sci. 2010. PMID: 20237252 Free PMC article.
Overexpression of VEGF165b in podocytes reduces glomerular permeability.
Qiu Y, Ferguson J, Oltean S, Neal CR, Kaura A, Bevan H, Wood E, Sage LM, Lanati S, Nowak DG, Salmon AH, Bates D, Harper SJ. Qiu Y, et al. J Am Soc Nephrol. 2010 Sep;21(9):1498-509. doi: 10.1681/ASN.2009060617. Epub 2010 Aug 5. J Am Soc Nephrol. 2010. PMID: 20688932 Free PMC article.
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