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Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures.
Du Z, Treiber D, McCarter JD, Fomina-Yadlin D, Saleem RA, McCoy RE, Zhang Y, Tharmalingam T, Leith M, Follstad BD, Dell B, Grisim B, Zupke C, Heath C, Morris AE, Reddy P. Du Z, et al. Biotechnol Bioeng. 2015 Jan;112(1):141-55. doi: 10.1002/bit.25332. Epub 2014 Sep 2. Biotechnol Bioeng. 2015. PMID: 25042542 Free PMC article.