Hayakawa H - Search Results

1

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants.

Kawamoto A, Kodama E, Sarafianos SG, Sakagami Y, Kohgo S, Kitano K, Ashida N, Iwai Y, Hayakawa H, Nakata H, Mitsuya H, Arnold E, Matsuoka M. Kawamoto A, et al. Among authors: hayakawa h. Int J Biochem Cell Biol. 2008;40(11):2410-20. doi: 10.1016/j.biocel.2008.04.007. Epub 2008 Apr 11. Int J Biochem Cell Biol. 2008. PMID: 18487070

2

Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides.

Kohgo S, Yamada K, Kitano K, Iwai Y, Sakata S, Ashida N, Hayakawa H, Nameki D, Kodama E, Matsuoka M, Mitsuya H, Ohrui H. Kohgo S, et al. Among authors: hayakawa h. Nucleosides Nucleotides Nucleic Acids. 2004;23(4):671-90. doi: 10.1081/NCN-120037508. Nucleosides Nucleotides Nucleic Acids. 2004. PMID: 15200030

3

Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV.

Kitano K, Kohgo S, Yamada K, Sakata S, Ashida N, Hayakawa H, Nameki D, Kodama E, Matsuoka M, Mitsuya H, Ohrui H. Kitano K, et al. Among authors: hayakawa h. Antivir Chem Chemother. 2004 May;15(3):161-7. doi: 10.1177/095632020401500306. Antivir Chem Chemother. 2004. PMID: 15266898 Free article.

4

Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.

Hayakawa H, Kohgo S, Kitano K, Ashida N, Kodama E, Mitsuya H, Ohrui H. Hayakawa H, et al. Antivir Chem Chemother. 2004 Jul;15(4):169-87. doi: 10.1177/095632020401500401. Antivir Chem Chemother. 2004. PMID: 15457679 Free article. Review.

5

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.

Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T, Mitsuya H. Ohrui H, et al. Among authors: hayakawa h. Nucleic Acids Symp Ser (Oxf). 2006;(50):1-2. doi: 10.1093/nass/nrl001. Nucleic Acids Symp Ser (Oxf). 2006. PMID: 17150787

6

Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine.

Nakata H, Amano M, Koh Y, Kodama E, Yang G, Bailey CM, Kohgo S, Hayakawa H, Matsuoka M, Anderson KS, Cheng YC, Mitsuya H. Nakata H, et al. Among authors: hayakawa h. Antimicrob Agents Chemother. 2007 Aug;51(8):2701-8. doi: 10.1128/AAC.00277-07. Epub 2007 Jun 4. Antimicrob Agents Chemother. 2007. PMID: 17548498 Free PMC article.

7

2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma.

Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T, Mitsuya H. Ohrui H, et al. Among authors: hayakawa h. Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1543-6. doi: 10.1080/15257770701545218. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18066823

8

Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.

Hattori S, Ide K, Nakata H, Harada H, Suzu S, Ashida N, Kohgo S, Hayakawa H, Mitsuya H, Okada S. Hattori S, et al. Among authors: hayakawa h. Antimicrob Agents Chemother. 2009 Sep;53(9):3887-93. doi: 10.1128/AAC.00270-09. Epub 2009 Jun 22. Antimicrob Agents Chemother. 2009. PMID: 19546363 Free PMC article.

9

Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.

Kohgo S, Yamada K, Kitano K, Sakata S, Hayakawa H, Nameki D, Kodama E, Matsuoka M, Mitsuya H, Ohrui H. Kohgo S, et al. Among authors: hayakawa h. Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):887-9. doi: 10.1081/NCN-120022678. Nucleosides Nucleotides Nucleic Acids. 2003. PMID: 14565303

10

Synthesis and antiviral evaluation of α-D-2',3'-didehydro-2',3'-dideoxy-3'-C-hydroxymethyl nucleosides.

Yamada K, Hayakawa H, Sakata S, Ashida N, Yoshimura Y. Yamada K, et al. Among authors: hayakawa h. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6013-6. doi: 10.1016/j.bmcl.2010.08.071. Epub 2010 Aug 21. Bioorg Med Chem Lett. 2010. PMID: 20833044

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