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Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Mayer SC, Banker AL, Boschelli F, Di L, Johnson M, Kenny CH, Krishnamurthy G, Kutterer K, Moy F, Petusky S, Ravi M, Tkach D, Tsou HR, Xu W. Mayer SC, et al. Among authors: boschelli f. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. doi: 10.1016/j.bmcl.2008.04.044. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18501599
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Miller LM, Mayer SC, Berger DM, Boschelli DH, Boschelli F, Di L, Du X, Dutia M, Floyd MB, Johnson M, Kenny CH, Krishnamurthy G, Moy F, Petusky S, Tkach D, Torres N, Wu B, Xu W. Miller LM, et al. Among authors: boschelli dh, boschelli f. Bioorg Med Chem Lett. 2009 Jan 1;19(1):62-6. doi: 10.1016/j.bmcl.2008.11.037. Epub 2008 Nov 17. Bioorg Med Chem Lett. 2009. PMID: 19041240
Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Gopalsamy A, Shi M, Golas J, Vogan E, Jacob J, Johnson M, Lee F, Nilakantan R, Petersen R, Svenson K, Chopra R, Tam MS, Wen Y, Ellingboe J, Arndt K, Boschelli F. Gopalsamy A, et al. Among authors: boschelli f. J Med Chem. 2008 Feb 14;51(3):373-5. doi: 10.1021/jm701385c. Epub 2008 Jan 16. J Med Chem. 2008. PMID: 18197612
4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.
Zhang N, Wu B, Boschelli DH, Golas JM, Boschelli F. Zhang N, et al. Among authors: boschelli dh, boschelli f. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5071-4. doi: 10.1016/j.bmcl.2009.07.043. Epub 2009 Jul 10. Bioorg Med Chem Lett. 2009. PMID: 19632113
A cell-based screen for inhibitors of protein folding and degradation.
Boschelli F, Golas JM, Petersen R, Lau V, Chen L, Tkach D, Zhao Q, Fruhling DS, Liu H, Nam C, Arndt KT. Boschelli F, et al. Cell Stress Chaperones. 2010 Nov;15(6):913-27. doi: 10.1007/s12192-010-0200-3. Epub 2010 Aug 19. Cell Stress Chaperones. 2010. PMID: 20717760 Free PMC article.
61 results