Shewchuk LM - Search Results

1

X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.

Biggadike K, Bledsoe RK, Hassell AM, Kirk BE, McLay IM, Shewchuk LM, Stewart EL. Biggadike K, et al. Among authors: shewchuk lm. J Med Chem. 2008 Jun 26;51(12):3349-52. doi: 10.1021/jm800279t. Epub 2008 Jun 4. J Med Chem. 2008. PMID: 18522385

2

Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.

Shewchuk L, Hassell A, Wisely B, Rocque W, Holmes W, Veal J, Kuyper LF. Shewchuk L, et al. J Med Chem. 2000 Jan 13;43(1):133-8. doi: 10.1021/jm990401t. J Med Chem. 2000. PMID: 10633045

3

Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.

Shewchuk LM, Hassell AM, Ellis B, Holmes WD, Davis R, Horne EL, Kadwell SH, McKee DD, Moore JT. Shewchuk LM, et al. Structure. 2000 Nov 15;8(11):1105-13. doi: 10.1016/s0969-2126(00)00516-5. Structure. 2000. PMID: 11080633 Free article.

4

Searching for antiviral drugs for human papillomaviruses.

Underwood MR, Shewchuk LM, Hassell AM, Phelps WC. Underwood MR, et al. Among authors: shewchuk lm. Antivir Ther. 2000 Dec;5(4):229-42. Antivir Ther. 2000. PMID: 11142617 Review.

5

Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.

Bramson HN, Corona J, Davis ST, Dickerson SH, Edelstein M, Frye SV, Gampe RT Jr, Harris PA, Hassell A, Holmes WD, Hunter RN, Lackey KE, Lovejoy B, Luzzio MJ, Montana V, Rocque WJ, Rusnak D, Shewchuk L, Veal JM, Walker DH, Kuyper LF. Bramson HN, et al. J Med Chem. 2001 Dec 6;44(25):4339-58. doi: 10.1021/jm010117d. J Med Chem. 2001. PMID: 11728181

6

Anilinopyrazole as selective CDK2 inhibitors: design, synthesis, biological evaluation, and X-ray crystallographic analysis.

Tang J, Shewchuk LM, Sato H, Hasegawa M, Washio Y, Nishigaki N. Tang J, et al. Among authors: shewchuk lm. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2985-8. doi: 10.1016/s0960-894x(03)00630-9. Bioorg Med Chem Lett. 2003. PMID: 12941317

7

Design of potent, selective, and orally bioavailable inhibitors of cysteine protease cathepsin k.

Tavares FX, Boncek V, Deaton DN, Hassell AM, Long ST, Miller AB, Payne AA, Miller LR, Shewchuk LM, Wells-Knecht K, Willard DH Jr, Wright LL, Zhou HQ. Tavares FX, et al. Among authors: shewchuk lm. J Med Chem. 2004 Jan 29;47(3):588-99. doi: 10.1021/jm030373l. J Med Chem. 2004. PMID: 14736240

8

Exploration of the P2-P3 SAR of aldehyde cathepsin K inhibitors.

Boros EE, Deaton DN, Hassell AM, McFadyen RB, Miller AB, Miller LR, Paulick MG, Shewchuk LM, Thompson JB, Willard DH Jr, Wright LL. Boros EE, et al. Among authors: shewchuk lm. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3425-9. doi: 10.1016/j.bmcl.2004.04.084. Bioorg Med Chem Lett. 2004. PMID: 15177446

9

Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with good pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions.

Barrett DG, Catalano JG, Deaton DN, Hassell AM, Long ST, Miller AB, Miller LR, Shewchuk LM, Wells-Knecht KJ, Willard DH Jr, Wright LL. Barrett DG, et al. Among authors: shewchuk lm. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4897-902. doi: 10.1016/j.bmcl.2004.07.031. Bioorg Med Chem Lett. 2004. PMID: 15341947

10

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.

Wood ER, Truesdale AT, McDonald OB, Yuan D, Hassell A, Dickerson SH, Ellis B, Pennisi C, Horne E, Lackey K, Alligood KJ, Rusnak DW, Gilmer TM, Shewchuk L. Wood ER, et al. Cancer Res. 2004 Sep 15;64(18):6652-9. doi: 10.1158/0008-5472.CAN-04-1168. Cancer Res. 2004. PMID: 15374980

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