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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.
Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ. Walensky LD, et al. Science. 2004 Sep 3;305(5689):1466-70. doi: 10.1126/science.1099191. Science. 2004. PMID: 15353804 Free PMC article.
A stapled BID BH3 helix directly binds and activates BAX.
Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ. Walensky LD, et al. Mol Cell. 2006 Oct 20;24(2):199-210. doi: 10.1016/j.molcel.2006.08.020. Mol Cell. 2006. PMID: 17052454 Free article.
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide.
Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. Bernal F, et al. Among authors: walensky ld. J Am Chem Soc. 2007 Mar 7;129(9):2456-7. doi: 10.1021/ja0693587. Epub 2007 Feb 7. J Am Chem Soc. 2007. PMID: 17284038 Free PMC article. No abstract available.
Dual role of proapoptotic BAD in insulin secretion and beta cell survival.
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Danial NN, et al. Among authors: walensky ld. Nat Med. 2008 Feb;14(2):144-53. doi: 10.1038/nm1717. Epub 2008 Jan 27. Nat Med. 2008. PMID: 18223655 Free PMC article.
BAX activation is initiated at a novel interaction site.
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. Gavathiotis E, et al. Among authors: walensky ld. Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396. Nature. 2008. PMID: 18948948 Free PMC article.
115 results