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Discovery of a highly orally bioavailable c-5-[6-(4-Methanesulfonyloxyphenyl)hexyl]-2-methyl-1,3-dioxane-r-2-carboxylic acid as a potent hypoglycemic and hypolipidemic agent.
Pingali H, Jain M, Shah S, Basu S, Makadia P, Goswami A, Zaware P, Patil P, Godha A, Giri S, Goel A, Patel M, Patel H, Patel P. Pingali H, et al. Among authors: patel h, patel m, patel p. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5586-90. doi: 10.1016/j.bmcl.2008.08.112. Epub 2008 Sep 3. Bioorg Med Chem Lett. 2008. PMID: 18805005
Design and synthesis of novel bis-oximinoalkanoic acids as potent PPAR alpha agonists.
Pingali H, Jain M, Shah S, Zaware P, Makadia P, Pola S, Thube B, Patel D, Patil P, Priyadarshini P, Suthar D, Shah M, Giri S, Patel P. Pingali H, et al. Among authors: patel p, patel d. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1156-61. doi: 10.1016/j.bmcl.2009.12.022. Epub 2009 Dec 6. Bioorg Med Chem Lett. 2010. PMID: 20022492
Modulation of PPAR subtype selectivity. Part 2: Transforming PPARα/γ dual agonist into α selective PPAR agonist through bioisosteric modification.
Zaware P, Shah SR, Pingali H, Makadia P, Thube B, Pola S, Patel D, Priyadarshini P, Suthar D, Shah M, Jamili J, Sairam KV, Giri S, Patel L, Patel H, Sudani H, Patel H, Jain M, Patel P, Bahekar R. Zaware P, et al. Among authors: patel h, patel l, patel p, patel d. Bioorg Med Chem Lett. 2011 Jan 15;21(2):628-32. doi: 10.1016/j.bmcl.2010.12.032. Epub 2010 Dec 10. Bioorg Med Chem Lett. 2011. PMID: 21195611
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Makadia P, Shah SR, Pingali H, Zaware P, Patel D, Pola S, Thube B, Priyadarshini P, Suthar D, Shah M, Giri S, Trivedi C, Jain M, Patel P, Bahekar R. Makadia P, et al. Among authors: patel p, patel d. Bioorg Med Chem. 2011 Jan 15;19(2):771-82. doi: 10.1016/j.bmc.2010.12.023. Epub 2010 Dec 13. Bioorg Med Chem. 2011. PMID: 21215640
Revisiting glitazars: thiophene substituted oxazole containing α-ethoxy phenylpropanoic acid derivatives as highly potent PPARα/γ dual agonists devoid of adverse effects in rodents.
Raval P, Jain M, Goswami A, Basu S, Gite A, Godha A, Pingali H, Raval S, Giri S, Suthar D, Shah M, Patel P. Raval P, et al. Among authors: patel p. Bioorg Med Chem Lett. 2011 May 15;21(10):3103-9. doi: 10.1016/j.bmcl.2011.03.020. Epub 2011 Mar 28. Bioorg Med Chem Lett. 2011. PMID: 21450468
Discovery of orally active, potent, and selective benzotriazole-based PTP1B inhibitors.
Patel D, Jain M, Shah SR, Bahekar R, Jadav P, Darji B, Siriki Y, Bandyopadhyay D, Joharapurkar A, Kshirsagar S, Patel H, Shaikh M, Sairam KV, Patel P. Patel D, et al. Among authors: patel h, patel p. ChemMedChem. 2011 Jun 6;6(6):1011-6. doi: 10.1002/cmdc.201100077. Epub 2011 Apr 19. ChemMedChem. 2011. PMID: 21506278 No abstract available.
Discovery of inhibitors of plasminogen activator inhibitor-1: structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives.
Pandya V, Jain M, Chakrabarti G, Soni H, Parmar B, Chaugule B, Patel J, Joshi J, Joshi N, Rath A, Raviya M, Shaikh M, Sairam KV, Patel H, Patel P. Pandya V, et al. Among authors: patel h, patel j, patel p. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5701-6. doi: 10.1016/j.bmcl.2011.08.031. Epub 2011 Aug 11. Bioorg Med Chem Lett. 2011. PMID: 21880486
8,559 results