Varki A - Search Results

1

B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase.

Cariappa A, Takematsu H, Liu H, Diaz S, Haider K, Boboila C, Kalloo G, Connole M, Shi HN, Varki N, Varki A, Pillai S. Cariappa A, et al. Among authors: varki a, varki n. J Exp Med. 2009 Jan 16;206(1):125-38. doi: 10.1084/jem.20081399. Epub 2008 Dec 22. J Exp Med. 2009. PMID: 19103880 Free PMC article.

2

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.

Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, MacDonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. Surolia I, et al. Among authors: varki a. Nature. 2010 Jul 8;466(7303):243-7. doi: 10.1038/nature09115. Epub 2010 Jun 16. Nature. 2010. PMID: 20555325 Free PMC article.

3

Diversity in cell surface sialic acid presentations: implications for biology and disease.

Varki NM, Varki A. Varki NM, et al. Among authors: varki a. Lab Invest. 2007 Sep;87(9):851-7. doi: 10.1038/labinvest.3700656. Epub 2007 Jul 16. Lab Invest. 2007. PMID: 17632542 Free PMC article. Review.

4

Genetically altered mice with different sialyltransferase deficiencies show tissue-specific alterations in sialylation and sialic acid 9-O-acetylation.

Martin LT, Marth JD, Varki A, Varki NM. Martin LT, et al. Among authors: varki a, varki nm. J Biol Chem. 2002 Sep 6;277(36):32930-8. doi: 10.1074/jbc.M203362200. Epub 2002 Jun 14. J Biol Chem. 2002. PMID: 12068010 Free article.

5

alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.

Hedlund M, Ng E, Varki A, Varki NM. Hedlund M, et al. Among authors: varki a, varki nm. Cancer Res. 2008 Jan 15;68(2):388-94. doi: 10.1158/0008-5472.CAN-07-1340. Cancer Res. 2008. PMID: 18199532

6

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus.

Ali SR, Fong JJ, Carlin AF, Busch TD, Linden R, Angata T, Areschoug T, Parast M, Varki N, Murray J, Nizet V, Varki A. Ali SR, et al. Among authors: varki a, varki n. J Exp Med. 2014 Jun 2;211(6):1231-42. doi: 10.1084/jem.20131853. Epub 2014 May 5. J Exp Med. 2014. PMID: 24799499 Free PMC article.

7

Developmental abnormalities in transgenic mice expressing a sialic acid-specific 9-O-acetylesterase.

Varki A, Hooshmand F, Diaz S, Varki NM, Hedrick SM. Varki A, et al. Among authors: varki nm. Cell. 1991 Apr 5;65(1):65-74. doi: 10.1016/0092-8674(91)90408-q. Cell. 1991. PMID: 1826463

8

Biochemical and genetic evidence for distinct membrane-bound and cytosolic sialic acid O-acetyl-esterases: serine-active-site enzymes.

Higa HH, Diaz S, Varki A. Higa HH, et al. Among authors: varki a. Biochem Biophys Res Commun. 1987 May 14;144(3):1099-108. doi: 10.1016/0006-291x(87)91425-2. Biochem Biophys Res Commun. 1987. PMID: 3107561

9

Lysosomal and cytosolic sialic acid 9-O-acetylesterase activities can Be encoded by one gene via differential usage of a signal peptide-encoding exon at the N terminus.

Takematsu H, Diaz S, Stoddart A, Zhang Y, Varki A. Takematsu H, et al. Among authors: varki a. J Biol Chem. 1999 Sep 3;274(36):25623-31. doi: 10.1074/jbc.274.36.25623. J Biol Chem. 1999. PMID: 10464298 Free article.

10

Sialic acid 9-O-acetylation on murine erythroleukemia cells affects complement activation, binding to I-type lectins, and tissue homing.

Shi WX, Chammas R, Varki NM, Powell L, Varki A. Shi WX, et al. Among authors: varki a, varki nm. J Biol Chem. 1996 Dec 6;271(49):31526-32. doi: 10.1074/jbc.271.49.31526. J Biol Chem. 1996. PMID: 8940168 Free article.

Indeed, the binding of human complement factor H, a negative regulator of the alternative pathway, is shown to be blocked by O-acetylation of the sialic acids on MEL cells. ...These data demonstrate that cell surface 9-O-acetylation can affect a variety of biologica …

Indeed, the binding of human complement factor H, a negative regulator of the alternative pathway, is shown to be blocked by O-acetyl …

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