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Epicardial border zone overexpression of skeletal muscle sodium channel SkM1 normalizes activation, preserves conduction, and suppresses ventricular arrhythmia: an in silico, in vivo, in vitro study.
Lau DH, Clausen C, Sosunov EA, Shlapakova IN, Anyukhovsky EP, Danilo P Jr, Rosen TS, Kelly C, Duffy HS, Szabolcs MJ, Chen M, Robinson RB, Lu J, Kumari S, Cohen IS, Rosen MR. Lau DH, et al. Among authors: chen m. Circulation. 2009 Jan 6;119(1):19-27. doi: 10.1161/CIRCULATIONAHA.108.809301. Epub 2008 Dec 22. Circulation. 2009. PMID: 19103989 Free PMC article.
SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic.
Boink GJ, Lau DH, Shlapakova IN, Sosunov EA, Anyukhovsky EP, Driessen HE, Dun W, Chen M, Danilo P Jr, Rosen TS, Őzgen N, Duffy HS, Kryukova Y, Boyden PA, Robinson RB, Brink PR, Cohen IS, Rosen MR. Boink GJ, et al. Among authors: chen m. Cardiovasc Res. 2012 Jun 1;94(3):450-9. doi: 10.1093/cvr/cvs107. Epub 2012 Feb 27. Cardiovasc Res. 2012. PMID: 22374989 Free PMC article.
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