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Bcl-2 family proteins as regulators of oxidative stress.
Susnow N, Zeng L, Margineantu D, Hockenbery DM. Susnow N, et al. Among authors: hockenbery dm. Semin Cancer Biol. 2009 Feb;19(1):42-9. doi: 10.1016/j.semcancer.2008.12.002. Epub 2008 Dec 24. Semin Cancer Biol. 2009. PMID: 19138742 Free PMC article. Review.
Cell 2000;100:57-70], relevant to tumorigenesis as well as resistance to cytotoxic drugs, and deregulation of Bcl-2 proteins is observed in many cancers [Manion MK, Hockenbery DM. Targeting BCL-2-related proteins in cancer therapy. Cancer Biol Ther. 2003;2:S105-14; …
Cell 2000;100:57-70], relevant to tumorigenesis as well as resistance to cytotoxic drugs, and deregulation of Bcl-2 proteins is observed in …
Hsp90 inhibition decreases mitochondrial protein turnover.
Margineantu DH, Emerson CB, Diaz D, Hockenbery DM. Margineantu DH, et al. Among authors: hockenbery dm. PLoS One. 2007 Oct 24;2(10):e1066. doi: 10.1371/journal.pone.0001066. PLoS One. 2007. PMID: 17957250 Free PMC article.
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
Berger S, Procko E, Margineantu D, Lee EF, Shen BW, Zelter A, Silva DA, Chawla K, Herold MJ, Garnier JM, Johnson R, MacCoss MJ, Lessene G, Davis TN, Stayton PS, Stoddard BL, Fairlie WD, Hockenbery DM, Baker D. Berger S, et al. Among authors: hockenbery dm. Elife. 2016 Nov 2;5:e20352. doi: 10.7554/eLife.20352. Elife. 2016. PMID: 27805565 Free PMC article.
Mitochondrial functions in stem cells.
Margineantu DH, Hockenbery DM. Margineantu DH, et al. Among authors: hockenbery dm. Curr Opin Genet Dev. 2016 Jun;38:110-117. doi: 10.1016/j.gde.2016.05.004. Epub 2016 Jun 5. Curr Opin Genet Dev. 2016. PMID: 27269732 Review.
Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism.
Davis RJ, Gönen M, Margineantu DH, Handeli S, Swanger J, Hoellerbauer P, Paddison PJ, Gu H, Raftery D, Grim JE, Hockenbery DM, Margolin AA, Clurman BE. Davis RJ, et al. Among authors: hockenbery dm. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5462-5467. doi: 10.1073/pnas.1718338115. Epub 2018 May 7. Proc Natl Acad Sci U S A. 2018. PMID: 29735700 Free PMC article.
Intracellular delivery system for antibody-Peptide drug conjugates.
Berguig GY, Convertine AJ, Frayo S, Kern HB, Procko E, Roy D, Srinivasan S, Margineantu DH, Booth G, Palanca-Wessels MC, Baker D, Hockenbery D, Press OW, Stayton PS. Berguig GY, et al. Mol Ther. 2015 May;23(5):907-917. doi: 10.1038/mt.2015.22. Epub 2015 Feb 11. Mol Ther. 2015. PMID: 25669432 Free PMC article.
123 results