Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies.
Rustenbeck I, Dickel C, Grimmsmanns T.
Rustenbeck I, et al.
Biochem Pharmacol. 2001 Dec 15;62(12):1695-703. doi: 10.1016/s0006-2952(01)00793-6.
Biochem Pharmacol. 2001.
PMID: 11755123
Prolonged in vitro exposure (18 h) of pancreatic islets to insulin secretagogues that block ATP-dependent K(+) channels (K(ATP) channels), such as sulfonylureas, imidazolines, and quinine, induced a desensitization of insulin secretion (Rustenbeck et al., pages 1685-1694, …
Prolonged in vitro exposure (18 h) of pancreatic islets to insulin secretagogues that block ATP-dependent K(+) channels (K(ATP) channels), s …