Fröhlich R - Search Results

1

Dancing of the second aromatic residue around the 6,8-diazabicyclo[3.2.2]nonane framework: influence on sigma receptor affinity and cytotoxicity.

Holl R, Schepmann D, Fröhlich R, Grünert R, Bednarski PJ, Wünsch B. Holl R, et al. Among authors: frohlich r. J Med Chem. 2009 Apr 9;52(7):2126-37. doi: 10.1021/jm801522j. J Med Chem. 2009. PMID: 19243173

2

Asymmetric synthesis of enantiomerically pure 2-substituted tetrahydro-3-benzazepines and their affinity to sigma1 receptors.

Husain SM, Fröhlich R, Schepmann D, Wünsch B. Husain SM, et al. Among authors: frohlich r. J Org Chem. 2009 Apr 3;74(7):2788-93. doi: 10.1021/jo900087e. J Org Chem. 2009. PMID: 19267485

3

Stereoselective synthesis and structure-affinity relationships of bicyclic kappa receptor agonists.

Kracht D, Rack E, Schepmann D, Fröhlich R, Wünsch B. Kracht D, et al. Among authors: frohlich r. Org Biomol Chem. 2010 Jan 7;8(1):212-25. doi: 10.1039/b915180j. Epub 2009 Nov 12. Org Biomol Chem. 2010. PMID: 20024152

4

Synthesis and biological evaluation of conformationally restricted σ(1) receptor ligands with 7,9-diazabicyclo[4.2.2]decane scaffold.

Sunnam SK, Schepmann D, Rack E, Fröhlich R, Korpis K, Bednarski PJ, Wünsch B. Sunnam SK, et al. Among authors: frohlich r. Org Biomol Chem. 2010 Dec 21;8(24):5525-40. doi: 10.1039/c0ob00402b. Epub 2010 Oct 15. Org Biomol Chem. 2010. PMID: 20953473

5

Design, synthesis and pharmacological evaluation of spirocyclic σ(1) receptor ligands with exocyclic amino moiety (increased distance 1).

Rack E, Fröhlich R, Schepmann D, Wünsch B. Rack E, et al. Among authors: frohlich r. Bioorg Med Chem. 2011 May 15;19(10):3141-51. doi: 10.1016/j.bmc.2011.04.002. Epub 2011 Apr 6. Bioorg Med Chem. 2011. PMID: 21531141

6

Asymmetric synthesis of 3-substituted tetrahydro-2-benzazepines.

Quick MP, Fröhlich R, Schepmann D, Wünsch B. Quick MP, et al. Among authors: frohlich r. Org Biomol Chem. 2015 Jul 14;13(26):7265-81. doi: 10.1039/c5ob00731c. Epub 2015 Jun 9. Org Biomol Chem. 2015. PMID: 26055189

7

Synthesis of bicyclic sigma receptor ligands with cytotoxic activity.

Geiger C, Zelenka C, Weigl M, Fröhlich R, Wibbeling B, Lehmkuhl K, Schepmann D, Grünert R, Bednarski PJ, Wünsch B. Geiger C, et al. Among authors: frohlich r. J Med Chem. 2007 Nov 29;50(24):6144-53. doi: 10.1021/jm070620b. Epub 2007 Oct 30. J Med Chem. 2007. PMID: 17967001

8

Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety.

Jung B, Englberger W, Fröhlich R, Schepmann D, Lehmkuhl K, Wünsch B. Jung B, et al. Among authors: frohlich r. Bioorg Med Chem. 2008 Mar 15;16(6):2870-85. doi: 10.1016/j.bmc.2008.01.004. Epub 2008 Jan 10. Bioorg Med Chem. 2008. PMID: 18249546

9

Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position.

Hasebein P, Frehland B, Lehmkuhl K, Fröhlich R, Schepmann D, Wünsch B. Hasebein P, et al. Among authors: frohlich r. Org Biomol Chem. 2014 Aug 7;12(29):5407-26. doi: 10.1039/c4ob00510d. Org Biomol Chem. 2014. PMID: 24934693

10

Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.

Molenveld P, Bouzanne des Mazery R, Sterk GJ, Storcken RP, Autar R, van Oss B, van der Haas RN, Fröhlich R, Schepmann D, Wünsch B, Soeberdt M. Molenveld P, et al. Among authors: frohlich r. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5326-30. doi: 10.1016/j.bmcl.2015.09.040. Epub 2015 Sep 16. Bioorg Med Chem Lett. 2015. PMID: 26411794

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