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Discovery of 4-(benzylaminomethylene)isoquinoline-1,3-(2H,4H)-diones and 4-[(pyridylmethyl)aminomethylene]isoquinoline-1,3-(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4.
J Med Chem. 2009 Apr 23;52(8):2289-310. doi: 10.1021/jm801026e.
J Med Chem. 2009.
PMID: 19317452
4-(Phenylaminomethylene)isoquinoline-1,3(2H,4H)-diones as potent and selective inhibitors of the cyclin-dependent kinase 4 (CDK4).
Tsou HR, Otteng M, Tran T, Floyd MB Jr, Reich M, Birnberg G, Kutterer K, Ayral-Kaloustian S, Ravi M, Nilakantan R, Grillo M, McGinnis JP, Rabindran SK.
Tsou HR, et al. Among authors: kutterer k.
J Med Chem. 2008 Jun 26;51(12):3507-25. doi: 10.1021/jm800072z.
J Med Chem. 2008.
PMID: 18494457
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Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.
Mayer SC, Banker AL, Boschelli F, Di L, Johnson M, Kenny CH, Krishnamurthy G, Kutterer K, Moy F, Petusky S, Ravi M, Tkach D, Tsou HR, Xu W.
Mayer SC, et al. Among authors: kutterer k.
Bioorg Med Chem Lett. 2008 Jun 15;18(12):3641-5. doi: 10.1016/j.bmcl.2008.04.044. Epub 2008 Apr 25.
Bioorg Med Chem Lett. 2008.
PMID: 18501599
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3,5-dioxopyrazolidines, novel inhibitors of UDP-N- acetylenolpyruvylglucosamine reductase (MurB) with activity against gram-positive bacteria.
Yang Y, Severin A, Chopra R, Krishnamurthy G, Singh G, Hu W, Keeney D, Svenson K, Petersen PJ, Labthavikul P, Shlaes DM, Rasmussen BA, Failli AA, Shumsky JS, Kutterer KM, Gilbert A, Mansour TS.
Yang Y, et al. Among authors: kutterer km.
Antimicrob Agents Chemother. 2006 Feb;50(2):556-64. doi: 10.1128/AAC.50.2.556-564.2006.
Antimicrob Agents Chemother. 2006.
PMID: 16436710
Free PMC article.
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4-Alkyl and 4,4'-dialkyl 1,2-bis(4-chlorophenyl)pyrazolidine-3,5-dione derivatives as new inhibitors of bacterial cell wall biosynthesis.
Kutterer KM, Davis JM, Singh G, Yang Y, Hu W, Severin A, Rasmussen BA, Krishnamurthy G, Failli A, Katz AH.
Kutterer KM, et al.
Bioorg Med Chem Lett. 2005 May 16;15(10):2527-31. doi: 10.1016/j.bmcl.2005.03.058.
Bioorg Med Chem Lett. 2005.
PMID: 15863310
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Alpha-galactose based neoglycopeptides. Inhibition of verotoxin binding to globotriosylceramide.
Arya P, Kutterer KM, Qin H, Roby J, Barnes ML, Lin S, Lingwood CA, Peter MG.
Arya P, et al. Among authors: kutterer km.
Bioorg Med Chem. 1999 Dec;7(12):2823-33. doi: 10.1016/s0968-0896(99)00226-6.
Bioorg Med Chem. 1999.
PMID: 10658586
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Diversity of C-linked neoglycopeptides for the exploration of subsite-assisted carbohydrate binding interactions.
Arya P, Kutterer KM, Qin H, Roby J, Barnes ML, Kim JM, Roy R.
Arya P, et al. Among authors: kutterer km.
Bioorg Med Chem Lett. 1998 May 19;8(10):1127-32. doi: 10.1016/s0960-894x(98)00182-6.
Bioorg Med Chem Lett. 1998.
PMID: 9871721
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Glycomimetics: a programmed approach toward neoglycopeptide libraries.
Arya P, Kutterer KM, Barkley A.
Arya P, et al. Among authors: kutterer km.
J Comb Chem. 2000 Mar-Apr;2(2):120-6. doi: 10.1021/cc990023d.
J Comb Chem. 2000.
PMID: 10757091
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