Elfringhoff AS - Search Results

1

1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues.

Bovens S, Kaptur M, Elfringhoff AS, Lehr M. Bovens S, et al. Among authors: elfringhoff as. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2107-11. doi: 10.1016/j.bmcl.2009.03.019. Epub 2009 Mar 10. Bioorg Med Chem Lett. 2009. PMID: 19327988

2

Structure-activity relationship studies of 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2alpha-mediated arachidonic acid release in intact platelets: variation of the keto moiety.

Ghasemi A, Elfringhoff AS, Lehr M. Ghasemi A, et al. Among authors: elfringhoff as. J Enzyme Inhib Med Chem. 2005 Oct;20(5):429-37. doi: 10.1080/14756360500228338. J Enzyme Inhib Med Chem. 2005. PMID: 16335050

3

Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha.

Ludwig J, Bovens S, Brauch C, Elfringhoff AS, Lehr M. Ludwig J, et al. Among authors: elfringhoff as. J Med Chem. 2006 Apr 20;49(8):2611-20. doi: 10.1021/jm051243a. J Med Chem. 2006. PMID: 16610804

4

1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility.

Fritsche A, Elfringhoff AS, Fabian J, Lehr M. Fritsche A, et al. Among authors: elfringhoff as. Bioorg Med Chem. 2008 Apr 1;16(7):3489-500. doi: 10.1016/j.bmc.2008.02.019. Epub 2008 Feb 13. Bioorg Med Chem. 2008. PMID: 18321717

5

1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase.

Forster L, Ludwig J, Kaptur M, Bovens S, Elfringhoff AS, Holtfrerich A, Lehr M. Forster L, et al. Among authors: elfringhoff as. Bioorg Med Chem. 2010 Jan 15;18(2):945-52. doi: 10.1016/j.bmc.2009.11.028. Epub 2009 Nov 17. Bioorg Med Chem. 2010. PMID: 20005725

6

Structure-activity relationship studies on 1-(5-carboxyindol-1-yl)-propan-2-one inhibitors of human cytosolic phospholipase A2α: variation of the activated ketone moiety.

Kaptur M, Elfringhoff AS, Lehr M. Kaptur M, et al. Among authors: elfringhoff as. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1773-6. doi: 10.1016/j.bmcl.2011.01.085. Epub 2011 Jan 22. Bioorg Med Chem Lett. 2011. PMID: 21316224

7

Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A₂α: Effect of substituents at the indole 3-position on activity, solubility, and metabolic stability.

Arnsmann M, Hanekamp W, Elfringhoff AS, Lehr M. Arnsmann M, et al. Among authors: elfringhoff as. Eur J Med Chem. 2017 Jan 5;125:1107-1114. doi: 10.1016/j.ejmech.2016.10.039. Epub 2016 Oct 21. Eur J Med Chem. 2017. PMID: 27810597

8

Comparison of the inhibition of the cytosolic phospholipase A2-mediated arachidonic acid release by several indole-2-carboxylic acids and 3-(pyrrol-2-yl)propionic acids in bovine and in human platelets.

Lehr M, Elfringhoff AS. Lehr M, et al. Among authors: elfringhoff as. Arch Pharm (Weinheim). 2000 Sep;333(9):312-4. doi: 10.1002/1521-4184(20009)333:9<312::aid-ardp312>3.0.co;2-y. Arch Pharm (Weinheim). 2000. PMID: 11039188

9

Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2).

Lehr M, Klimt M, Elfringhoff AS. Lehr M, et al. Among authors: elfringhoff as. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2569-72. doi: 10.1016/s0960-894x(01)00472-3. Bioorg Med Chem Lett. 2001. PMID: 11551751

10

Determination of the cell lytic properties of amphiphilic inhibitors of the cytosolic phospholipase A2 against human platelets by measuring the liberation of serotonin with high-performance liquid chromatography and fluorescence detection.

Risse D, Elfringhoff AS, Lehr M. Risse D, et al. Among authors: elfringhoff as. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Mar 25;769(1):185-90. doi: 10.1016/s1570-0232(02)00013-2. J Chromatogr B Analyt Technol Biomed Life Sci. 2002. PMID: 11936691

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