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Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity.
Kobayashi K, Kato T, Yamamoto I, Shimizu A, Mizutani S, Asai M, Kawamoto H, Ito S, Yoshizumi T, Hirayama M, Ozaki S, Ohta H, Okamoto O. Kobayashi K, et al. Among authors: shimizu a. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3100-3. doi: 10.1016/j.bmcl.2009.04.022. Epub 2009 Apr 11. Bioorg Med Chem Lett. 2009. PMID: 19398200
Novel ORL1-selective antagonists with oral bioavailability and brain penetrability.
Okamoto O, Kobayashi K, Kawamoto H, Ito S, Yoshizumi T, Yamamoto I, Hashimoto M, Shimizu A, Takahashi H, Ishii Y, Ozaki S, Ohta H. Okamoto O, et al. Among authors: shimizu a. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3282-5. doi: 10.1016/j.bmcl.2008.04.037. Epub 2008 Apr 28. Bioorg Med Chem Lett. 2008. PMID: 18448337
Identification of novel benzimidazole series of potent and selective ORL1 antagonists.
Okamoto O, Kobayashi K, Kawamoto H, Ito S, Satoh A, Kato T, Yamamoto I, Mizutani S, Hashimoto M, Shimizu A, Sakoh H, Nagatomi Y, Iwasawa Y, Takahashi H, Ishii Y, Ozaki S, Ohta H. Okamoto O, et al. Among authors: shimizu a. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3278-81. doi: 10.1016/j.bmcl.2008.04.054. Epub 2008 Apr 25. Bioorg Med Chem Lett. 2008. PMID: 18468891
2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists.
Kobayashi K, Uchiyama M, Takahashi H, Kawamoto H, Ito S, Yoshizumi T, Nakashima H, Kato T, Shimizu A, Yamamoto I, Asai M, Miyazoe H, Ohno A, Hirayama M, Ozaki S, Tani T, Ishii Y, Tanaka T, Mochidome T, Tadano K, Fukuroda T, Ohta H, Okamoto O. Kobayashi K, et al. Among authors: shimizu a. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3096-9. doi: 10.1016/j.bmcl.2009.04.023. Epub 2009 Apr 11. Bioorg Med Chem Lett. 2009. PMID: 19394217
Conversion of the thioether linkage of the prototype [It is reported prior to this communication as a consecutive series.: Kobayashi, K.; Kato, T.; Yamamoto, I.; Shimizu, A.; Mizutani, S.; Asai, M.; Kawamoto, H.; Ito, S.; Yoshizumi, T.; Hirayama, M.; Ozaki, S …
Conversion of the thioether linkage of the prototype [It is reported prior to this communication as a consecutive series.: Kobayashi, …
Evaluating Cellularity Estimation Methods: Comparing AI Counting with Pathologists' Visual Estimates.
Kiyuna T, Cosatto E, Hatanaka KC, Yokose T, Tsuta K, Motoi N, Makita K, Shimizu A, Shinohara T, Suzuki A, Takakuwa E, Takakuwa Y, Tsuji T, Tsujiwaki M, Yanai M, Yuzawa S, Ogura M, Hatanaka Y. Kiyuna T, et al. Among authors: shimizu a. Diagnostics (Basel). 2024 May 28;14(11):1115. doi: 10.3390/diagnostics14111115. Diagnostics (Basel). 2024. PMID: 38893641
2,903 results