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Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage.
Zhu Y, Gumlaw N, Karman J, Zhao H, Zhang J, Jiang JL, Maniatis P, Edling A, Chuang WL, Siegel C, Shayman JA, Kaplan J, Jiang C, Cheng SH. Zhu Y, et al. Among authors: zhang j. J Biol Chem. 2011 Apr 29;286(17):14787-94. doi: 10.1074/jbc.M111.218610. Epub 2011 Mar 14. J Biol Chem. 2011. PMID: 21402703 Free PMC article.
Glycoengineered acid alpha-glucosidase with improved efficacy at correcting the metabolic aberrations and motor function deficits in a mouse model of Pompe disease.
Zhu Y, Jiang JL, Gumlaw NK, Zhang J, Bercury SD, Ziegler RJ, Lee K, Kudo M, Canfield WM, Edmunds T, Jiang C, Mattaliano RJ, Cheng SH. Zhu Y, et al. Among authors: zhang j. Mol Ther. 2009 Jun;17(6):954-63. doi: 10.1038/mt.2009.37. Epub 2009 Mar 10. Mol Ther. 2009. PMID: 19277015 Free PMC article.
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