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Page 1
Discovery of the development candidate N-tert-butyl nodulisporamide: a safe and efficacious once monthly oral agent for the control of fleas and ticks on companion animals.
Meinke PT, Colletti SL, Fisher MH, Wyvratt MJ, Shih TL, Ayer MB, Li C, Lim J, Ok D, Salva S, Warmke LM, Zakson M, Michael BF, Demontigny P, Ostlind DA, Fink D, Drag M, Schmatz DM, Shoop WL. Meinke PT, et al. Among authors: ayer mb. J Med Chem. 2009 Jun 11;52(11):3505-15. doi: 10.1021/jm801334v. J Med Chem. 2009. PMID: 19445514
Nodulisporic acid side-chain modifications: access to the 2", 3", 4", and 6" registers.
Chakravarty PK, Shih TL, Colletti SL, Ayer MB, Snedden C, Kuo H, Tyagarajan S, Gregory L, Zakson-Aiken M, Shoop WL, Schmatz DM, Wyvratt M, Fisher MH, Meinke PT. Chakravarty PK, et al. Among authors: ayer mb. Bioorg Med Chem Lett. 2003 Jan 6;13(1):147-50. doi: 10.1016/s0960-894x(02)00826-0. Bioorg Med Chem Lett. 2003. PMID: 12467636
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT. Colletti SL, et al. Among authors: ayer mb. Bioorg Med Chem Lett. 2001 Jan 22;11(2):107-11. doi: 10.1016/s0960-894x(00)00604-1. Bioorg Med Chem Lett. 2001. PMID: 11206438
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT. Colletti SL, et al. Among authors: ayer mb. Bioorg Med Chem Lett. 2001 Jan 22;11(2):113-7. doi: 10.1016/s0960-894x(00)00605-3. Bioorg Med Chem Lett. 2001. PMID: 11206439
Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits.
Ludmerer SW, Warren VA, Williams BS, Zheng Y, Hunt DC, Ayer MB, Wallace MA, Chaudhary AG, Egan MA, Meinke PT, Dean DC, Garcia ML, Cully DF, Smith MM. Ludmerer SW, et al. Among authors: ayer mb. Biochemistry. 2002 May 21;41(20):6548-60. doi: 10.1021/bi015920o. Biochemistry. 2002. PMID: 12009920