Roche D - Search Results

1

Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.

Lepifre F, Christmann-Franck S, Roche D, Leriche C, Carniato D, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E. Lepifre F, et al. Among authors: roche d. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3682-5. doi: 10.1016/j.bmcl.2009.02.123. Epub 2009 Mar 5. Bioorg Med Chem Lett. 2009. PMID: 19450980

2

Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Roche D, Carniato D, Leriche C, Lepifre F, Christmann-Franck S, Graedler U, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E. Roche D, et al. Bioorg Med Chem Lett. 2009 May 15;19(10):2674-8. doi: 10.1016/j.bmcl.2009.03.140. Epub 2009 Apr 1. Bioorg Med Chem Lett. 2009. PMID: 19395260

3

Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I.

Valeur E, Christmann-Franck S, Lepifre F, Carniato D, Cravo D, Charon C, Bozec S, Musil D, Hillertz P, Doare L, Schmidlin F, Lecomte M, Schultz M, Roche D. Valeur E, et al. Among authors: roche d. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5909-14. doi: 10.1016/j.bmcl.2012.07.070. Epub 2012 Jul 31. Bioorg Med Chem Lett. 2012. PMID: 22901389

4

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.

Grädler U, Schwarz D, Blaesse M, Leuthner B, Johnson TL, Bernard F, Jiang X, Marx A, Gilardone M, Lemoine H, Roche D, Jorand-Lebrun C. Grädler U, et al. Among authors: roche d. Bioorg Med Chem Lett. 2019 Dec 1;29(23):126717. doi: 10.1016/j.bmcl.2019.126717. Epub 2019 Oct 16. Bioorg Med Chem Lett. 2019. PMID: 31635932 Free PMC article.

5

Design and synthesis of potent and selective inhibitors of integrin VLA-4.

Wattanasin S, Weidmann B, Roche D, Myers S, Xing A, Guo Q, Sabio M, von Matt P, Hugo R, Maida S, Lake P, Weetall M. Wattanasin S, et al. Among authors: roche d. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2955-8. doi: 10.1016/s0960-894x(01)00586-8. Bioorg Med Chem Lett. 2001. PMID: 11677134

6

Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A26771B.

Canova S, Lépine R, Thys A, Baron A, Roche D. Canova S, et al. Among authors: roche d. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4768-72. doi: 10.1016/j.bmcl.2011.06.073. Epub 2011 Jun 23. Bioorg Med Chem Lett. 2011. PMID: 21767951

7

New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space.

Brethon A, Chantalat L, Christin O, Clary L, Fournier JF, Gastreich M, Harris CS, Isabet T, Pascau J, Thoreau E, Roche D, Rodeschini V. Brethon A, et al. Among authors: roche d. Bioorg Med Chem Lett. 2017 Dec 15;27(24):5373-5377. doi: 10.1016/j.bmcl.2017.11.015. Epub 2017 Nov 9. Bioorg Med Chem Lett. 2017. PMID: 29157864

8

1,4-Diazepane-2-ones as novel inhibitors of LFA-1.

Wattanasin S, Albert R, Ehrhardt C, Roche D, Sabio M, Hommel U, Welzenbach K, Weitz-Schmidt G. Wattanasin S, et al. Among authors: roche d. Bioorg Med Chem Lett. 2003 Feb 10;13(3):499-502. doi: 10.1016/s0960-894x(02)00991-5. Bioorg Med Chem Lett. 2003. PMID: 12565959

9

Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.

Tahtouh T, Durieu E, Villiers B, Bruyère C, Nguyen TL, Fant X, Ahn KH, Khurana L, Deau E, Lindberg MF, Sévère E, Miege F, Roche D, Limanton E, L'Helgoual'ch JM, Burgy G, Guiheneuf S, Herault Y, Kendall DA, Carreaux F, Bazureau JP, Meijer L. Tahtouh T, et al. Among authors: roche d. J Med Chem. 2022 Jan 27;65(2):1396-1417. doi: 10.1021/acs.jmedchem.1c01141. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928152

10

Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries.

Craven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden SP, Nelson A. Craven P, et al. Among authors: roche d. Bioorg Med Chem. 2015 Jun 1;23(11):2629-35. doi: 10.1016/j.bmc.2014.12.048. Epub 2014 Dec 29. Bioorg Med Chem. 2015. PMID: 25600406

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