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Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Wu J, Green N, Hotchandani R, Hu Y, Condon J, Huang A, Kaila N, Li HQ, Guler S, Li W, Tam SY, Wang Q, Pelker J, Marusic S, Hsu S, Perry Hall J, Telliez JB, Cui J, Lin LL. Wu J, et al. Among authors: pelker j. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3485-8. doi: 10.1016/j.bmcl.2009.05.009. Epub 2009 May 7. Bioorg Med Chem Lett. 2009. PMID: 19464884
TH1-mediated airway hyperresponsiveness independent of neutrophilic inflammation.
Cui J, Pazdziorko S, Miyashiro JS, Thakker P, Pelker JW, Declercq C, Jiao A, Gunn J, Mason L, Leonard JP, Williams CM, Marusic S. Cui J, et al. Among authors: pelker jw. J Allergy Clin Immunol. 2005 Feb;115(2):309-15. doi: 10.1016/j.jaci.2004.10.046. J Allergy Clin Immunol. 2005. PMID: 15696086
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
Carter LL, Leach MW, Azoitei ML, Cui J, Pelker JW, Jussif J, Benoit S, Ireland G, Luxenberg D, Askew GR, Milarski KL, Groves C, Brown T, Carito BA, Percival K, Carreno BM, Collins M, Marusic S. Carter LL, et al. Among authors: pelker jw. J Neuroimmunol. 2007 Jan;182(1-2):124-34. doi: 10.1016/j.jneuroim.2006.10.006. Epub 2006 Dec 19. J Neuroimmunol. 2007. PMID: 17182110
Blockade of cytosolic phospholipase A2 alpha prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses.
Marusic S, Thakker P, Pelker JW, Stedman NL, Lee KL, McKew JC, Han L, Xu X, Wolf SF, Borey AJ, Cui J, Shen MW, Donahue F, Hassan-Zahraee M, Leach MW, Shimizu T, Clark JD. Marusic S, et al. Among authors: pelker jw. J Neuroimmunol. 2008 Nov 15;204(1-2):29-37. doi: 10.1016/j.jneuroim.2008.08.012. J Neuroimmunol. 2008. PMID: 18829119
Human bronchial epithelial cells express and secrete MMP-12.
Lavigne MC, Thakker P, Gunn J, Wong A, Miyashiro JS, Wasserman AM, Wei SQ, Pelker JW, Kobayashi M, Eppihimer MJ. Lavigne MC, et al. Among authors: pelker jw. Biochem Biophys Res Commun. 2004 Nov 12;324(2):534-46. doi: 10.1016/j.bbrc.2004.09.080. Biochem Biophys Res Commun. 2004. PMID: 15474460
Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
Su Z, Brooks J, Pelker J, Andreyeva T, Sobon H, Gifford R, Powers M, Wang J, Dower C, Hegen M, Messing D, Sheehan AD, Brennan JJ. Su Z, et al. Among authors: pelker j. PLoS One. 2023 Jan 20;18(1):e0280590. doi: 10.1371/journal.pone.0280590. eCollection 2023. PLoS One. 2023. PMID: 36662882 Free PMC article.
Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
Green N, Hu Y, Janz K, Li HQ, Kaila N, Guler S, Thomason J, Joseph-McCarthy D, Tam SY, Hotchandani R, Wu J, Huang A, Wang Q, Leung L, Pelker J, Marusic S, Hsu S, Telliez JB, Hall JP, Cuozzo JW, Lin LL. Green N, et al. Among authors: pelker j. J Med Chem. 2007 Sep 20;50(19):4728-45. doi: 10.1021/jm070436q. Epub 2007 Aug 23. J Med Chem. 2007. PMID: 17715908