Polokoff MA - Search Results

1

Potent triazolothione inhibitor of heat-shock protein-90.

Feldman RI, Mintzer B, Zhu D, Wu JM, Biroc SL, Yuan S, Emayan K, Chang Z, Chen D, Arnaiz DO, Bryant J, Ge XS, Whitlow M, Adler M, Polokoff MA, Li WW, Ferrer M, Sato T, Gu JM, Shen J, Tseng JL, Dinter H, Buckman B. Feldman RI, et al. Among authors: polokoff ma. Chem Biol Drug Des. 2009 Jul;74(1):43-50. doi: 10.1111/j.1747-0285.2009.00833.x. Chem Biol Drug Des. 2009. PMID: 19519743

2

Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1.

Feldman RI, Wu JM, Polokoff MA, Kochanny MJ, Dinter H, Zhu D, Biroc SL, Alicke B, Bryant J, Yuan S, Buckman BO, Lentz D, Ferrer M, Whitlow M, Adler M, Finster S, Chang Z, Arnaiz DO. Feldman RI, et al. Among authors: polokoff ma. J Biol Chem. 2005 May 20;280(20):19867-74. doi: 10.1074/jbc.M501367200. Epub 2005 Mar 16. J Biol Chem. 2005. PMID: 15772071 Free article.

3

1-(1,3-Benzodioxol-5-ylmethyl)-3-[4-(1H-imidazol-1-yl)phenoxy]-piperidine analogs as potent and selective inhibitors of nitric oxide formation.

Wei RG, Adler M, Davey D, Ho E, Mohan R, Polokoff M, Tseng JL, Whitlow M, Xu W, Yuan S, Phillips G. Wei RG, et al. Bioorg Med Chem Lett. 2007 May 1;17(9):2499-504. doi: 10.1016/j.bmcl.2007.02.053. Epub 2007 Feb 27. Bioorg Med Chem Lett. 2007. PMID: 17368901

4

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517.

Islam I, Brown G, Bryant J, Hrvatin P, Kochanny MJ, Phillips GB, Yuan S, Adler M, Whitlow M, Lentz D, Polokoff MA, Wu J, Shen J, Walters J, Ho E, Subramanyam B, Zhu D, Feldman RI, Arnaiz DO. Islam I, et al. Among authors: polokoff ma. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25. doi: 10.1016/j.bmcl.2007.05.060. Epub 2007 May 23. Bioorg Med Chem Lett. 2007. PMID: 17544272

5

Antibodies neutralizing hepsin protease activity do not impact cell growth but inhibit invasion of prostate and ovarian tumor cells in culture.

Xuan JA, Schneider D, Toy P, Lin R, Newton A, Zhu Y, Finster S, Vogel D, Mintzer B, Dinter H, Light D, Parry R, Polokoff M, Whitlow M, Wu Q, Parry G. Xuan JA, et al. Cancer Res. 2006 Apr 1;66(7):3611-9. doi: 10.1158/0008-5472.CAN-05-2983. Cancer Res. 2006. PMID: 16585186

6

The rational design of inhibitors of nitric oxide formation by inducible nitric oxide synthase.

Whitlow M, Adler M, Davey D, Huang Q, Koovakkat S, Parkinson JF, Pham E, Polokoff M, Xu W, Yuan S, Phillips G. Whitlow M, et al. Bioorg Med Chem Lett. 2007 May 1;17(9):2505-8. doi: 10.1016/j.bmcl.2007.02.018. Epub 2007 Feb 9. Bioorg Med Chem Lett. 2007. PMID: 17336523

7

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.

Islam I, Bryant J, Chou YL, Kochanny MJ, Lee W, Phillips GB, Yu H, Adler M, Whitlow M, Ho E, Lentz D, Polokoff MA, Subramanyam B, Wu JM, Zhu D, Feldman RI, Arnaiz DO. Islam I, et al. Among authors: polokoff ma. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8. doi: 10.1016/j.bmcl.2007.04.071. Epub 2007 Apr 27. Bioorg Med Chem Lett. 2007. PMID: 17531483

8

Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.

Davey DD, Adler M, Arnaiz D, Eagen K, Erickson S, Guilford W, Kenrick M, Morrissey MM, Ohlmeyer M, Pan G, Paradkar VM, Parkinson J, Polokoff M, Saionz K, Santos C, Subramanyam B, Vergona R, Wei RG, Whitlow M, Ye B, Zhao ZS, Devlin JJ, Phillips G. Davey DD, et al. J Med Chem. 2007 Mar 22;50(6):1146-57. doi: 10.1021/jm061319i. Epub 2007 Feb 23. J Med Chem. 2007. PMID: 17315988

9

Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors.

Blasko E, Glaser CB, Devlin JJ, Xia W, Feldman RI, Polokoff MA, Phillips GB, Whitlow M, Auld DS, McMillan K, Ghosh S, Stuehr DJ, Parkinson JF. Blasko E, et al. Among authors: polokoff ma. J Biol Chem. 2002 Jan 4;277(1):295-302. doi: 10.1074/jbc.M105691200. Epub 2001 Oct 31. J Biol Chem. 2002. PMID: 11689556 Free article.

10

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.

Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Yang L, et al. Cancer Res. 2004 Jul 1;64(13):4394-9. doi: 10.1158/0008-5472.CAN-04-0343. Cancer Res. 2004. PMID: 15231645

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