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The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex.
Tricklebank MD, Bristow LJ, Hutson PH, Leeson PD, Rowley M, Saywell K, Singh L, Tattersall FD, Thorn L, Williams BJ. Tricklebank MD, et al. Among authors: singh l. Br J Pharmacol. 1994 Nov;113(3):729-36. doi: 10.1111/j.1476-5381.1994.tb17054.x. Br J Pharmacol. 1994. PMID: 7858861 Free PMC article.
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.
Singh L, Donald AE, Foster AC, Hutson PH, Iversen LL, Iversen SD, Kemp JA, Leeson PD, Marshall GR, Oles RJ, et al. Singh L, et al. Proc Natl Acad Sci U S A. 1990 Jan;87(1):347-51. doi: 10.1073/pnas.87.1.347. Proc Natl Acad Sci U S A. 1990. PMID: 2153294 Free PMC article.
1,958 results