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Dynamic telomerase gene suppression via network effects of GSK3 inhibition.
Bilsland AE, Hoare S, Stevenson K, Plumb J, Gomez-Roman N, Cairney C, Burns S, Lafferty-Whyte K, Roffey J, Hammonds T, Keith WN. Bilsland AE, et al. Among authors: roffey j. PLoS One. 2009 Jul 31;4(7):e6459. doi: 10.1371/journal.pone.0006459. PLoS One. 2009. PMID: 19649288 Free PMC article.
Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma.
Lafferty-Whyte K, Bilsland A, Cairney CJ, Hanley L, Jamieson NB, Zaffaroni N, Oien KA, Burns S, Roffey J, Boyd SM, Keith WN. Lafferty-Whyte K, et al. Among authors: roffey j. BMC Genomics. 2010 Oct 1;11:532. doi: 10.1186/1471-2164-11-532. BMC Genomics. 2010. PMID: 20920304 Free PMC article.
Cancer cell senescence: a new frontier in drug development.
Cairney CJ, Bilsland AE, Evans TR, Roffey J, Bennett DC, Narita M, Torrance CJ, Keith WN. Cairney CJ, et al. Among authors: roffey j. Drug Discov Today. 2012 Mar;17(5-6):269-76. doi: 10.1016/j.drudis.2012.01.019. Epub 2012 Jan 31. Drug Discov Today. 2012. PMID: 22314100 Review.
Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes.
Kjær S, Linch M, Purkiss A, Kostelecky B, Knowles PP, Rosse C, Riou P, Soudy C, Kaye S, Patel B, Soriano E, Murray-Rust J, Barton C, Dillon C, Roffey J, Parker PJ, McDonald NQ. Kjær S, et al. Among authors: roffey j. Biochem J. 2013 Apr 15;451(2):329-42. doi: 10.1042/BJ20121871. Biochem J. 2013. PMID: 23418854
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment.
Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE. Mirza AN, et al. Among authors: roffey j. JCI Insight. 2017 Nov 2;2(21):e97071. doi: 10.1172/jci.insight.97071. JCI Insight. 2017. PMID: 29093271 Free PMC article.
Protein kinase C intervention: the state of play.
Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. Roffey J, et al. Curr Opin Cell Biol. 2009 Apr;21(2):268-79. doi: 10.1016/j.ceb.2009.01.019. Epub 2009 Feb 23. Curr Opin Cell Biol. 2009. PMID: 19233632 Review.
18 results