Koch U - Search Results

1

Optimization of thienopyrrole-based finger-loop inhibitors of the hepatitis C virus NS5B polymerase.

Martin Hernando JI, Ontoria JM, Malancona S, Attenni B, Fiore F, Bonelli F, Koch U, Di Marco S, Colarusso S, Ponzi S, Gennari N, Vignetti SE, Del Rosario Rico Ferreira M, Habermann J, Rowley M, Narjes F. Martin Hernando JI, et al. Among authors: koch u. ChemMedChem. 2009 Oct;4(10):1695-713. doi: 10.1002/cmdc.200900184. ChemMedChem. 2009. PMID: 19672916

2

Recent developments in the discovery of hepatitis C virus serine protease inhibitors--towards a new class of antiviral agents?

Narjes F, Koch U, Steinkühler C. Narjes F, et al. Among authors: koch u. Expert Opin Investig Drugs. 2003 Feb;12(2):153-63. doi: 10.1517/13543784.12.2.153. Expert Opin Investig Drugs. 2003. PMID: 12556211 Review.

3

Interdomain communication in hepatitis C virus polymerase abolished by small molecule inhibitors bound to a novel allosteric site.

Di Marco S, Volpari C, Tomei L, Altamura S, Harper S, Narjes F, Koch U, Rowley M, De Francesco R, Migliaccio G, Carfí A. Di Marco S, et al. Among authors: koch u. J Biol Chem. 2005 Aug 19;280(33):29765-70. doi: 10.1074/jbc.M505423200. Epub 2005 Jun 13. J Biol Chem. 2005. PMID: 15955819 Free article.

4

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F. Koch U, et al. J Med Chem. 2006 Mar 9;49(5):1693-705. doi: 10.1021/jm051064t. J Med Chem. 2006. PMID: 16509585

5

Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase.

Ontoria JM, Martìn Hernando JI, Malancona S, Attenni B, Stansfield I, Conte I, Ercolani C, Habermann J, Ponzi S, Di Filippo M, Koch U, Rowley M, Narjes F. Ontoria JM, et al. Among authors: koch u. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4026-30. doi: 10.1016/j.bmcl.2006.05.012. Epub 2006 May 22. Bioorg Med Chem Lett. 2006. PMID: 16714108

6

Allosteric inhibition of the hepatitis C virus NS5B RNA dependent RNA polymerase.

Koch U, Narjes F. Koch U, et al. Infect Disord Drug Targets. 2006 Mar;6(1):31-41. doi: 10.2174/187152606776056724. Infect Disord Drug Targets. 2006. PMID: 16787302 Review.

7

Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.

Koch U, Narjes F. Koch U, et al. Curr Top Med Chem. 2007;7(13):1302-29. doi: 10.2174/156802607781212211. Curr Top Med Chem. 2007. PMID: 17627559 Review.

8

Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase.

Habermann J, Capitò E, Ferreira Mdel R, Koch U, Narjes F. Habermann J, et al. Among authors: koch u. Bioorg Med Chem Lett. 2009 Feb 1;19(3):633-8. doi: 10.1016/j.bmcl.2008.12.039. Epub 2008 Dec 13. Bioorg Med Chem Lett. 2009. PMID: 19109015

9

Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase.

Stansfield I, Ercolani C, Mackay A, Conte I, Pompei M, Koch U, Gennari N, Giuliano C, Rowley M, Narjes F. Stansfield I, et al. Among authors: koch u. Bioorg Med Chem Lett. 2009 Feb 1;19(3):627-32. doi: 10.1016/j.bmcl.2008.12.068. Epub 2008 Dec 24. Bioorg Med Chem Lett. 2009. PMID: 19131244

10

Identification and biological evaluation of a series of 1H-benzo[de]isoquinoline-1,3(2H)-diones as hepatitis C virus NS5B polymerase inhibitors.

Ontoria JM, Rydberg EH, Di Marco S, Tomei L, Attenni B, Malancona S, Martin Hernando JI, Gennari N, Koch U, Narjes F, Rowley M, Summa V, Carroll SS, Olsen DB, De Francesco R, Altamura S, Migliaccio G, Carfì A. Ontoria JM, et al. Among authors: koch u. J Med Chem. 2009 Aug 27;52(16):5217-27. doi: 10.1021/jm900517t. J Med Chem. 2009. PMID: 19877603

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