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HIV-specific cytotoxic cell frequencies measured directly ex vivo by the Lysispot assay can be higher or lower than the frequencies of IFN-gamma-secreting cells: anti-HIV cytotoxicity is not generally impaired relative to other chronic virus responses.
Snyder-Cappione JE, Divekar AA, Maupin GM, Jin X, Demeter LM, Mosmann TR. Snyder-Cappione JE, et al. J Immunol. 2006 Feb 15;176(4):2662-8. doi: 10.4049/jimmunol.176.4.2662. J Immunol. 2006. PMID: 16456029
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